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Its pathophysiology is not yet fully understood and involves multiple factors, including mechanical, cellular and molecular factors. The circadian rhythm has been shown to be a major regulator of extracellular matrix (ECM) homeostasis in several connective tissues, including tendon. Very recently, the human patellar tendon has been established as a peripheral clock tissue that exhibits dampening with chronic tendinopathy, and this\u00a0has important translational and clinical relevance. This review summarises what is currently known about the role of the tendon circadian clock in collagen and tendon ECM homeostasis and proposes a role for circadian clock disruption in tendinopathy. A better understanding of the mechanisms that regulate tendon clock synchronisation could guide the development of new therapeutic strategies for managing tendon overuse injuries.<\/jats:p>","DOI":"10.1111\/iep.70001","type":"journal-article","created":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T05:35:26Z","timestamp":1746077726000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Role of the tendon circadian clock in tendinopathy and implications for therapeutics"],"prefix":"10.1111","volume":"106","author":[{"given":"Ask","family":"M\u00f8bjerg","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery, Institute of Sports Medicine Copenhagen Copenhagen University Hospital \u2013 Bispebjerg and Frederiksberg  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara Dietz","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Institute of Sports Medicine Copenhagen Copenhagen University Hospital \u2013 Bispebjerg and Frederiksberg  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Kjaer","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Institute of Sports Medicine Copenhagen Copenhagen University Hospital \u2013 Bispebjerg and Frederiksberg  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7076-8109","authenticated-orcid":false,"given":"Ching\u2010Yan Chlo\u00e9","family":"Yeung","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Institute of Sports Medicine Copenhagen Copenhagen University Hospital \u2013 Bispebjerg and Frederiksberg  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,30]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2010.43"},{"key":"e_1_2_14_3_1","unstructured":"BevanS QuadrelloT McGeeR MahdonM VavrovskyA BarhamL.Fit for work? 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