{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T12:22:15Z","timestamp":1790166135450,"version":"4.1.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["international-journal-of-gynecological-cancer.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Gynecological Cancer"],"published-print":{"date-parts":[[2010,5]]},"DOI":"10.1111\/igc.0b013e3181c7fe6e","type":"journal-article","created":{"date-parts":[[2010,12,3]],"date-time":"2010-12-03T14:05:26Z","timestamp":1291385126000},"page":"513-519","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":56,"title":["Quantitative Analysis of Methylation Status of the PAX1 Gene for Detection of Cervical Cancer"],"prefix":"10.1016","volume":"20","author":[{"given":"Tien-Hung","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hung-Chen","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hwan-Wun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuei Jyuan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai-Hung","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dah-Ching","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tang-Yuan","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1111\/IGC.0b013e3181c7fe6e_bb0005","doi-asserted-by":"crossref","first-page":"3030","DOI":"10.1002\/ijc.21731","article-title":"The global health burden of infection-associated cancers in the year 2002","volume":"118","author":"Parkin","year":"2006","journal-title":"Int J Cancer."},{"key":"10.1111\/IGC.0b013e3181c7fe6e_bb0010","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1002\/cncr.11507","article-title":"Atypical squamous cells of undetermined significance in liquid-based cytologic specimens: results of reflex human papillomavirus testing and histologic follow-up in routine practice with comparison of interpretive and probabilistic reporting methods","volume":"99","author":"Levi","year":"2003","journal-title":"Cancer."},{"key":"10.1111\/IGC.0b013e3181c7fe6e_bb0015","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1038\/sj.bjc.6604262","article-title":"Long-term outcomes of high-risk human papillomavirus infection support a long interval of cervical cancer screening","volume":"98","author":"Huang","year":"2008","journal-title":"Br J Cancer."},{"key":"10.1111\/IGC.0b013e3181c7fe6e_bb0020","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.a1754","article-title":"Long term predictive values of cytology and human papillomavirus testing in cervical cancer screening: joint European cohort study","volume":"337","author":"Dillner","year":"2008","journal-title":"BMJ."},{"key":"10.1111\/IGC.0b013e3181c7fe6e_bb0025","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/5947","article-title":"Cancer epigenetics comes of age","volume":"21","author":"Jones","year":"1999","journal-title":"Nat Genet."},{"key":"10.1111\/IGC.0b013e3181c7fe6e_bb0030","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.cell.2007.01.029","article-title":"The epigenomics of cancer","volume":"128","author":"Jones","year":"2007","journal-title":"Cell."},{"key":"10.1111\/IGC.0b013e3181c7fe6e_bb0035","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1093\/jnci\/djh031","article-title":"TSLC1 gene silencing in cervical cancer cell lines and cervical neoplasia","volume":"96","author":"Steenbergen","year":"2004","journal-title":"J Natl Cancer Inst."},{"key":"10.1111\/IGC.0b013e3181c7fe6e_bb0040","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1093\/jnci\/dji041","article-title":"Detection of hypermethylated genes in women with and without cervical neoplasia","volume":"97","author":"Feng","year":"2005","journal-title":"J Natl Cancer Inst."},{"key":"10.1111\/IGC.0b013e3181c7fe6e_bb0045","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.ygyno.2006.10.003","article-title":"Hypermethylation of two consecutive tumor suppressor genes, BLU and RASSF1A, located at 3p21.3 in cervical neoplasias","volume":"104","author":"Lai","year":"2007","journal-title":"Gynecol Oncol."},{"key":"10.1111\/IGC.0b013e3181c7fe6e_bb0050","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1002\/cncr.23258","article-title":"Quantitative methylation-specific PCR for the detection of aberrant DNA methylation in liquid-based Pap tests","volume":"114","author":"Kahn","year":"2008","journal-title":"Cancer."},{"key":"10.1111\/IGC.0b013e3181c7fe6e_bb0055","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1002\/ijc.23519","article-title":"Identification of novel DNA methylation markers in cervical cancer","volume":"123","author":"Lai","year":"2008","journal-title":"Int J Cancer."},{"key":"10.1111\/IGC.0b013e3181c7fe6e_bb0060","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1038\/sj.ejhg.5200987","article-title":"Mutations in PAX1 may be associated with Klippel-Feil syndrome","volume":"11","author":"McGaughran","year":"2003","journal-title":"Eur J Hum Genet."},{"key":"10.1111\/IGC.0b013e3181c7fe6e_bb0065","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1242\/dev.122.1.23","article-title":"Pax1 is expressed during development of the thymus epithelium and is required for normal T-cell maturation","volume":"122","author":"Wallin","year":"1996","journal-title":"Development."},{"key":"10.1111\/IGC.0b013e3181c7fe6e_bb0070","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/S0888-7543(05)80177-6","article-title":"Pax1, a member of the paired box-containing class of developmental control genes, is mapped to human chromosome 20p11.2 by in situ hybridization (ISH and FISH)","volume":"14","author":"Schnittger","year":"1992","journal-title":"Genomics."},{"key":"10.1111\/IGC.0b013e3181c7fe6e_bb0075","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1002\/ijc.23957","article-title":"An epigenetic marker panel for screening and prognostic prediction of ovarian cancer","volume":"124","author":"Su","year":"2009","journal-title":"Int J Cancer."},{"key":"10.1111\/IGC.0b013e3181c7fe6e_bb0080","doi-asserted-by":"crossref","first-page":"E32","DOI":"10.1093\/nar\/28.8.e32","article-title":"MethyLight: a high-throughput assay to measure DNA methylation","volume":"28","author":"Eads","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"10.1111\/IGC.0b013e3181c7fe6e_bb0085","doi-asserted-by":"crossref","first-page":"209","DOI":"10.2353\/jmoldx.2006.050135","article-title":"Precision and performance characteristics of bisulfite conversion and real-time PCR (MethyLight) for quantitative DNA methylation analysis","volume":"8","author":"Ogino","year":"2006","journal-title":"J Mol Diagn."},{"key":"10.1111\/IGC.0b013e3181c7fe6e_bb0090","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/29.9.e45","article-title":"A new mathematical model for relative quantification in real-time RT-PCR","volume":"29","author":"Pfaffl","year":"2001","journal-title":"Nucleic Acids Res."},{"key":"10.1111\/IGC.0b013e3181c7fe6e_bb0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bcp.2006.06.024","article-title":"PAX genes: roles in development, pathophysiology, and cancer","volume":"73","author":"Lang","year":"2007","journal-title":"Biochem Pharmacol."},{"key":"10.1111\/IGC.0b013e3181c7fe6e_bb0100","doi-asserted-by":"crossref","first-page":"13439","DOI":"10.1073\/pnas.0605926103","article-title":"A Drosophila model of the rhabdomyosarcoma initiator PAX7-FKHR","volume":"103","author":"Galindo","year":"2006","journal-title":"Proc Natl Acad Sci U SA."},{"key":"10.1111\/IGC.0b013e3181c7fe6e_bb0105","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1182\/blood-2006-03-009670","article-title":"Oncogenic role of Pax5 in the T-lymphoid lineage upon ectopic expression from the immunoglobulin heavy-chain locus","volume":"109","author":"Souabni","year":"2007","journal-title":"Blood."},{"key":"10.1111\/IGC.0b013e3181c7fe6e_bb0110","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/nrc1778","article-title":"A PANorama of PAX genes in cancer and development","volume":"6","author":"Robson","year":"2006","journal-title":"Nat Rev Cancer."},{"key":"10.1111\/IGC.0b013e3181c7fe6e_bb0115","first-page":"3369","article-title":"The expression of PAX6, PTEN, vascular endothelial growth factor, and epidermal growth factor receptor in gliomas: relationship to tumor grade and survival","volume":"9","author":"Zhou","year":"2003","journal-title":"Clin Cancer Res."},{"key":"10.1111\/IGC.0b013e3181c7fe6e_bb0120","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/path.1115","article-title":"Progressive loss of PAX9 expression correlates with increasing malignancy of dysplastic and cancerous epithelium of the human oesophagus","volume":"197","author":"Gerber","year":"2002","journal-title":"J Pathol."},{"key":"10.1111\/IGC.0b013e3181c7fe6e_bb0125","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s11060-004-1720-4","article-title":"PAX6 suppresses growth of human glioblastoma cells","volume":"71","author":"Zhou","year":"2005","journal-title":"J Neurooncol."},{"key":"10.1111\/IGC.0b013e3181c7fe6e_bb0130","first-page":"1065","article-title":"PAX4 has the potential to function as a tumor suppressor in human melanoma","volume":"33","author":"Hata","year":"2008","journal-title":"Int J Oncol."},{"key":"10.1111\/IGC.0b013e3181c7fe6e_bb0135","doi-asserted-by":"crossref","first-page":"152","DOI":"10.2353\/jmoldx.2006.060026","article-title":"Quantitative DNA methylation analysis: the promise of high-throughput epigenomic diagnostic testing in human neoplastic disease","volume":"8","author":"Coleman","year":"2006","journal-title":"J Mol Diagn."},{"key":"10.1111\/IGC.0b013e3181c7fe6e_bb0140","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1111\/j.1349-7006.2009.01285.x","article-title":"Field methylation silencing of the protocadherin 10 gene in cervical carcinogenesis as a potential specific diagnostic test from cervical scrapings","volume":"100","author":"Wang","year":"2009","journal-title":"Cancer Sci."},{"key":"10.1111\/IGC.0b013e3181c7fe6e_bb0145","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1093\/jnci\/djj051","article-title":"Gene promoter methylation in prostate tumor\u2013associated stromal cells","volume":"98","author":"Hanson","year":"2006","journal-title":"J Natl Cancer Inst."},{"key":"10.1111\/IGC.0b013e3181c7fe6e_bb0150","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.cell.2007.01.029","article-title":"The epigenomics of cancer","volume":"128","author":"Jones","year":"2007","journal-title":"Cell."},{"key":"10.1111\/IGC.0b013e3181c7fe6e_bb0155","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1038\/sj.bjc.6604262","article-title":"Long-term outcomes of high-risk human papillomavirus infection support a long interval of cervical cancer screening","volume":"98","author":"Huang","year":"2008","journal-title":"Br J Cancer."}],"container-title":["International Journal of Gynecological Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2FIGC.0b013e3181c7fe6e","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1048891X24036247?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1048891X24036247?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T01:17:51Z","timestamp":1753233471000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1048891X24036247"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,5]]}},"alternative-id":["S1048891X24036247"],"URL":"https:\/\/doi.org\/10.1111\/igc.0b013e3181c7fe6e","relation":{},"ISSN":["1048-891X"],"issn-type":[{"value":"1048-891X","type":"print"}],"subject":[],"published":{"date-parts":[[2010,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Quantitative Analysis of Methylation Status of the PAX1 Gene for Detection of Cervical Cancer","name":"articletitle","label":"Article Title"},{"value":"International Journal of Gynecological Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1111\/IGC.0b013e3181c7fe6e","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 by IGCS and ESGO","name":"copyright","label":"Copyright"}]}}