{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:52:07Z","timestamp":1787014327105,"version":"build-2736575974"},"reference-count":34,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["international-journal-of-gynecological-cancer.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Gynecological Cancer"],"published-print":{"date-parts":[[2010,7]]},"DOI":"10.1111\/igc.0b013e3181e513e5","type":"journal-article","created":{"date-parts":[[2010,12,3]],"date-time":"2010-12-03T14:34:58Z","timestamp":1291386898000},"page":"1011-1016","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Association Between Serum Cytokine Profiles and Clearance or Persistence of High Risk Human Papillomavirus Infection"],"prefix":"10.1016","volume":"20","author":[{"given":"Jin Hwa","family":"Hong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi Kyung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In Ho","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Jin","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"San Ha","family":"Kwak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Hun","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Kwan","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1111\/IGC.0b013e3181e513e5_bb0005","unstructured":"Bosch FX, Lorincz A, Munoz N, et al. The causal relation between human papillomavirus and cervical cancer."},{"key":"10.1111\/IGC.0b013e3181e513e5_bb0015","unstructured":"Bosch FX, Manos MM, Munoz N, et al. Prevalence of human papillomavirus in cervical cancer: a worldwide perspective."},{"key":"10.1111\/IGC.0b013e3181e513e5_bb0025","first-page":"1026Y1030","article-title":"Human papillomavirus infection is transient in young women: a population-based","volume":"171","author":"Evander","year":"1995","journal-title":"cohort study"},{"key":"10.1111\/IGC.0b013e3181e513e5_bb0030","first-page":"423Y428","article-title":"Natural history of cervicovaginal papillomavirus infection in young","volume":"338","author":"Ho","year":"1998","journal-title":"women"},{"key":"10.1111\/IGC.0b013e3181e513e5_bb0035","unstructured":"Koutsky LA, Holmes KK, Critchlow CW, et al. A cohort study of the risk of cervical intraepithelial neoplasia grade 2 or 3 in relation to papillomavirus infection."},{"key":"10.1111\/IGC.0b013e3181e513e5_bb0045","doi-asserted-by":"crossref","first-page":"130Y139","DOI":"10.1006\/viro.1994.1171","article-title":"Regulation of early gene expression of human papillomavirus type 16 by inflammatory cytokines","volume":"200","author":"Kyo","year":"1994","journal-title":"Virology."},{"key":"10.1111\/IGC.0b013e3181e513e5_bb0050","first-page":"342-350","article-title":"Papillomaviruses and cancer: from basic studies to clinical application","volume":"2","author":"Zur","year":"2002","journal-title":"Nat Rev Cancer."},{"key":"10.1111\/IGC.0b013e3181e513e5_bb0055","doi-asserted-by":"crossref","first-page":"76-102","DOI":"10.1086\/317537","article-title":"Type 1\/type 2 immunity in infectious diseases","volume":"32","author":"Spellberg","year":"2001","journal-title":"Clin Infect Dis."},{"key":"10.1111\/IGC.0b013e3181e513e5_bb0060","doi-asserted-by":"crossref","first-page":"227-257","DOI":"10.1146\/annurev.iy.12.040194.001303","article-title":"Lymphokine production by human T cells in disease states","volume":"12","author":"Romagnani","year":"1994","journal-title":"Annu Rev Immunol."},{"key":"10.1111\/IGC.0b013e3181e513e5_bb0065","doi-asserted-by":"crossref","first-page":"185-186","DOI":"10.1093\/jnci\/89.3.185","article-title":"Analysis of cytokine profiles in patients with human papillomavirus-associated neoplasms","volume":"89","author":"Wu","year":"1997","journal-title":"J Natl Cancer Inst."},{"key":"10.1111\/IGC.0b013e3181e513e5_bb0070","doi-asserted-by":"crossref","first-page":"745-756","DOI":"10.1038\/nri1184","article-title":"Signaling pathways of the TNF superfamily: a double-edged sword","volume":"3","author":"Aggarwal","year":"2003","journal-title":"Nat Rev Immunol."},{"key":"10.1111\/IGC.0b013e3181e513e5_bb0075","doi-asserted-by":"crossref","first-page":"331Y339","DOI":"10.1016\/S0166-3542(02)00070-0","article-title":"Interleukin-10 induces transcription of the early promoter of human papillomavirus type 16 (HPV 16) through the 5-segment of the upstream regulatory region (URR)","volume":"55","author":"Arany","year":"2002","journal-title":"Antiviral Res."},{"key":"10.1111\/IGC.0b013e3181e513e5_bb0080","doi-asserted-by":"crossref","first-page":"961-964","DOI":"10.1111\/j.1471-0528.2006.00956.x","article-title":"The IL-10 1082G polymorphism is associated with clearance of HPV infection","volume":"113","author":"Farzaneh","year":"2006","journal-title":"BJOG."},{"key":"10.1111\/IGC.0b013e3181e513e5_bb0085","doi-asserted-by":"crossref","first-page":"209-220","DOI":"10.1128\/CDLI.8.2.209-220.2001","article-title":"Cell-mediated immune response to human papillomavirus infection","volume":"8","author":"Scott","year":"2001","journal-title":"Clin Diagn Lab Immunol."},{"key":"10.1111\/IGC.0b013e3181e513e5_bb0090","doi-asserted-by":"crossref","first-page":"285-291","DOI":"10.1006\/gyno.1999.5358","article-title":"Increased IL-6 and IL-8 levels in cervicovaginal secretions of patients with cervical cancer","volume":"73","author":"Tjiong","year":"1999","journal-title":"Gynecol Oncol."},{"key":"10.1111\/IGC.0b013e3181e513e5_bb0095","doi-asserted-by":"crossref","first-page":"49-56","DOI":"10.1006\/gyno.2001.6235","article-title":"Interleukin-6 in cervical cancer: the relationship with vascular endothelial growth factor","volume":"82","author":"Wei","year":"2001","journal-title":"Gynecol Oncol."},{"key":"10.1111\/IGC.0b013e3181e513e5_bb0100","doi-asserted-by":"crossref","unstructured":"Castellsague X, Munoz N. Chapter 3: cofactors in human papillomavirus carcinogenesis-role of parity, oral contraceptives, and tobacco smoking. J Natl Cancer Inst Monogr. 2003;31:20-28.","DOI":"10.1093\/oxfordjournals.jncimonographs.a003477"},{"key":"10.1111\/IGC.0b013e3181e513e5_bb0105","doi-asserted-by":"crossref","first-page":"11070","DOI":"10.1158\/0008-5472.CAN-06-2034","article-title":"Persistent human papillomavirus infection is associated with a generalized decrease in immune responsiveness in older women","volume":"66","author":"Garcia-Pineres","year":"2006","journal-title":"Cancer Res."},{"key":"10.1111\/IGC.0b013e3181e513e5_bb0110","doi-asserted-by":"crossref","first-page":"879-885","DOI":"10.1136\/ijgc-00009577-200707000-00019","article-title":"Cytokine profile in Indian women with cervical intraepithelial neoplasia and cancer cervix","volume":"17","author":"Sharma","year":"2007","journal-title":"Int J Gynecol Cancer."},{"key":"10.1111\/IGC.0b013e3181e513e5_bb0115","doi-asserted-by":"crossref","first-page":"245-250","DOI":"10.1093\/jnci\/89.3.245","article-title":"Cytokine production patterns in cervical intraepithelial neoplasia: association with human papillomavirus infection","volume":"89","author":"Clerici","year":"1997","journal-title":"J Natl Cancer Inst."},{"key":"10.1111\/IGC.0b013e3181e513e5_bb0120","first-page":"533-545","article-title":"Increased number of IL-2, IL-2 receptor and IL-10 positive cells in premalignant lesions of the cervix","volume":"49","author":"Mindiola","year":"2008","journal-title":"Invest Clin."},{"key":"10.1111\/IGC.0b013e3181e513e5_bb0125","first-page":"543Y548","article-title":"Interferon-F (IFN-F): a possible prognostic marker for clearance of high-risk human papillomavirus (HPV)","volume":"108","author":"Song","year":"2007","journal-title":"Gynecol Oncol."},{"key":"10.1111\/IGC.0b013e3181e513e5_bb0130","first-page":"456-463","article-title":"Leukoregulin and gamma-interferon inhibit human papillomavirus type 16 gene transcription in human papillomavirus immortalized human cervical cells","volume":"52","author":"Woodworth","year":"1992","journal-title":"Cancer Res."},{"key":"10.1111\/IGC.0b013e3181e513e5_bb0135","first-page":"636-641","article-title":"Frequent display of human papillomavirus type 16 E6-specific memory T-helper cells in the healthy population as witness of previous viral encounter","volume":"63","author":"Welters","year":"2003","journal-title":"Cancer Res."},{"key":"10.1111\/IGC.0b013e3181e513e5_bb0140","first-page":"285-289","article-title":"Correlation of tissue and plasma RANTES levels with disease course in patients with breast or cervical cancer","volume":"7","author":"Niwa","year":"2001","journal-title":"Clin Cancer Res."},{"key":"10.1111\/IGC.0b013e3181e513e5_bb0145","doi-asserted-by":"crossref","first-page":"170-171","DOI":"10.1006\/gyno.2001.6361","article-title":"Serum cytokine concentrations in patients with cervical cancer: interleukin-4, interferon-gamma, and monocyte chemoattractant protein-1: to the editor","volume":"83","author":"Lebrecht","year":"2001","journal-title":"Gynecol Oncol."},{"key":"10.1111\/IGC.0b013e3181e513e5_bb0150","doi-asserted-by":"crossref","first-page":"97Y109","DOI":"10.1002\/(SICI)1098-2744(200002)27:2<97::AID-MC5>3.0.CO;2-V","article-title":"Tumor necrosis factor-alpha promotes human papillomavirus (HPV) E6\/E7 RNA expression and cyclin-dependent kinase activity in HPV-immortalized keratinocytes by a ras-dependent pathway","volume":"27","author":"Gaiotti","year":"2000","journal-title":"Mol Carcinog."},{"key":"10.1111\/IGC.0b013e3181e513e5_bb0155","doi-asserted-by":"crossref","first-page":"1096-1100","DOI":"10.1136\/jcp.2004.025072","article-title":"A shift to a peripheral Th2-type cytokine pattern during the carcinogenesis of cervical cancer becomes manifest in CIN III lesions","volume":"58","author":"Bais","year":"2005","journal-title":"J Clin Pathol."},{"key":"10.1111\/IGC.0b013e3181e513e5_bb0160","doi-asserted-by":"crossref","first-page":"253-278","DOI":"10.1146\/annurev.iy.08.040190.001345","article-title":"Interleukin-6: an overview","volume":"8","author":"van Snick","year":"1990","journal-title":"Ann Rev Immunol."},{"key":"10.1111\/IGC.0b013e3181e513e5_bb0165","first-page":"944-952","article-title":"Interleukin-6 and interleukin-6 soluble receptor regulate proliferation of normal, human papillomavirus-immortalized, and carcinoma-derived cervical cells in vitro","volume":"146","author":"Iglesias","year":"1995","journal-title":"Am J Pathol."},{"key":"10.1111\/IGC.0b013e3181e513e5_bb0170","doi-asserted-by":"crossref","first-page":"2371-2376","DOI":"10.1084\/jem.180.6.2371","article-title":"Interleukin 10 pretreatment protects target cells from tumor- and allo-specific cytotoxic T cells and downregulates HLA class I expression","volume":"180","author":"Matsuda","year":"1994","journal-title":"JExp Med."},{"key":"10.1111\/IGC.0b013e3181e513e5_bb0175","first-page":"219-224","article-title":"Inverse modulation of IL-10 and IL-12 in the blood of women with preneoplastic lesions of the uterine cervix","volume":"111","author":"Jacobs","year":"1998","journal-title":"Clin Exp Immunol."},{"key":"10.1111\/IGC.0b013e3181e513e5_bb0190","doi-asserted-by":"crossref","first-page":"1376-1384","DOI":"10.1016\/j.humpath.2004.08.012","article-title":"Increased secretion patterns of interleukin-10 and tumor necrosis factor-alpha in cervical squamous intraepithelial lesions","volume":"35","author":"Azar","year":"2004","journal-title":"Hum Pathol."},{"key":"10.1111\/IGC.0b013e3181e513e5_bb0195","doi-asserted-by":"crossref","first-page":"23-27","DOI":"10.1023\/A:1014252402630","article-title":"Cervical concentrations of interleukin-10 and interleukin-12 do not correlate with plasma levels","volume":"22","author":"Castle","year":"2002","journal-title":"J Clin Immunol."}],"container-title":["International Journal of Gynecological Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2FIGC.0b013e3181e513e5","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1048891X24058535?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1048891X24058535?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1111\/IGC.0b013e3181e513e5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T01:08:33Z","timestamp":1753232913000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1048891X24058535"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["S1048891X24058535"],"URL":"https:\/\/doi.org\/10.1111\/igc.0b013e3181e513e5","relation":{},"ISSN":["1048-891X"],"issn-type":[{"value":"1048-891X","type":"print"}],"subject":[],"published":{"date-parts":[[2010,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association Between Serum Cytokine Profiles and Clearance or Persistence of High Risk Human Papillomavirus Infection","name":"articletitle","label":"Article Title"},{"value":"International Journal of Gynecological Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1111\/IGC.0b013e3181e513e5","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 by IGCS and ESGO","name":"copyright","label":"Copyright"}]}}