{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T22:46:21Z","timestamp":1776465981555,"version":"3.51.2"},"reference-count":33,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["international-journal-of-gynecological-cancer.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Gynecological Cancer"],"published-print":{"date-parts":[[2010,10]]},"DOI":"10.1111\/igc.0b013e3181ef8deb","type":"journal-article","created":{"date-parts":[[2010,12,3]],"date-time":"2010-12-03T14:29:09Z","timestamp":1291386549000},"page":"1154-1159","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":52,"title":["Systemic Leukocyte Alterations Are Associated With Invasive Uterine Cervical Cancer"],"prefix":"10.1016","volume":"20","author":[{"given":"Beatriz M.","family":"Tavares-Murta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria A.O.","family":"Mendonoa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia L.","family":"Duarte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana A.","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taciana S.","family":"Mut\u00e3o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristiana B.","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eddie F.C.","family":"Murta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1111\/IGC.0b013e3181ef8deb_bb0005","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/nature01322","article-title":"Inflammation and cancer","volume":"420","author":"Coussens","year":"2002","journal-title":"Nature"},{"key":"10.1111\/IGC.0b013e3181ef8deb_bb0010","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/S0140-6736(00)04046-0","article-title":"Inflammation and cancer: back to Virchow?","volume":"357","author":"Balkwill","year":"2001","journal-title":"Lancet"},{"key":"10.1111\/IGC.0b013e3181ef8deb_bb0015","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1093\/jnci\/90.21.1583","article-title":"Tumor-associated macrophages as targets for cancer therapy","volume":"90","author":"Wahl","year":"1998","journal-title":"J Natl Cancer Inst"},{"key":"10.1111\/IGC.0b013e3181ef8deb_bb0020","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1002\/(SICI)1097-0215(19970529)71:5<724::AID-IJC6>3.0.CO;2-T","article-title":"Tumor-associated lympho-monocytes from neoplastic effusions are immunologically defective in comparison with patient autologus PBMCs but are capable of releasing high amounts of various cytokines","volume":"71","author":"Mantovani","year":"1997","journal-title":"Int J Cancer"},{"key":"10.1111\/IGC.0b013e3181ef8deb_bb0025","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1177\/030089160409000509","article-title":"Differential tumor microenvironment in human ovarian cystic tumors","volume":"90","author":"Tavares-Murta","year":"2004","journal-title":"Tumori"},{"key":"10.1111\/IGC.0b013e3181ef8deb_bb0030","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/j.1600-065X.2008.00607.x","article-title":"The yin-yang of tumor-associated macrophages in neoplastic progression and immune surveillance","volume":"222","author":"Allavena","year":"2008","journal-title":"Immunol Rev"},{"key":"10.1111\/IGC.0b013e3181ef8deb_bb0035","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1111\/j.1525-1438.2007.00922.x","article-title":"Circulating neutrophils may play a role in the host response in cervical cancer","volume":"17","author":"Fernandes","year":"2007","journal-title":"Int J Gynecol Cancer"},{"key":"10.1111\/IGC.0b013e3181ef8deb_bb0040","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1023\/A:1012527006566","article-title":"Alterations of routine blood tests in adult patients with soft tissue sarcomas: relationships to cytokine serum levels and prognostic significance","volume":"12","author":"Ruka","year":"2001","journal-title":"Ann Oncol"},{"key":"10.1111\/IGC.0b013e3181ef8deb_bb0045","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/jso.20329","article-title":"Neutrophil-lymphocyte ratio as a prognostic factor in colorectal cancer","volume":"91","author":"Walsh","year":"2005","journal-title":"J Surg Oncol"},{"key":"10.1111\/IGC.0b013e3181ef8deb_bb0050","doi-asserted-by":"crossref","first-page":"2714","DOI":"10.1158\/1055-9965.EPI-08-0042","article-title":"Physical activity, white blood cell count, and lung cancer risk in a prospective cohort study","volume":"17","author":"Sprague","year":"2008","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1111\/IGC.0b013e3181ef8deb_bb0055","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1007\/s00432-008-0378-2","article-title":"Baseline elevated leukocyte count in peripheral blood is associated with poor survival in patients with advanced non-small cell lung cancer: a prognostic model","volume":"134","author":"Tibaldi","year":"2008","journal-title":"J Cancer Res Clin Oncol"},{"key":"10.1111\/IGC.0b013e3181ef8deb_bb0060","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1136\/jcp.2004.025072","article-title":"A shift to a peripheral TH2-type cytokine pattern during the carcinogenesis of cervical cancer becomes manifest in CIN III lesions","volume":"58","author":"Bais","year":"2005","journal-title":"J Clin Pathol"},{"key":"10.1111\/IGC.0b013e3181ef8deb_bb0065","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/sj.bjc.6602702","article-title":"Elevated neutrophil and monocyte counts in peripheral blood are associated with poor survival in patients with metastatic melanoma: a prognostic model","volume":"93","author":"Schmidt","year":"2005","journal-title":"Br J Cancer"},{"key":"10.1111\/IGC.0b013e3181ef8deb_bb0070","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1097\/01.mpa.0000188305.90290.50","article-title":"Decreased total lymphocyte counts in pancreatic cancer: an index of adverse outcome","volume":"32","author":"Fogar","year":"2006","journal-title":"Pancreas"},{"key":"10.1111\/IGC.0b013e3181ef8deb_bb0075","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1200\/JCO.2005.03.9594","article-title":"Impact of immune parameters on long-term survival in metastatic renal cell carcinoma","volume":"24","author":"Donskov","year":"2006","journal-title":"J Clin Oncol"},{"key":"10.1111\/IGC.0b013e3181ef8deb_bb0080","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1200\/JCO.2006.09.0274","article-title":"Pretreatment levels of peripheral neutrophils and leukocytes as independent predictors of overall survival in patients with American Joint Committee on Cancer Stage IV Melanoma: results of the EORTC 18951 Biochemotherapy Trial","volume":"25","author":"Schmidt","year":"2007","journal-title":"J Clin Oncol"},{"key":"10.1111\/IGC.0b013e3181ef8deb_bb0085","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1016\/j.ejca.2009.01.023","article-title":"Pretreatment neutrophil count as an independent prognostic factor in advanced non-small-cell lung cancer: an analysis of Japan Multinational Trial Organisation LC00-03 [published online ahead of print]","volume":"45","author":"Teramukai","year":"2009","journal-title":"Eur J Cancer"},{"key":"10.1111\/IGC.0b013e3181ef8deb_bb0090","first-page":"775","article-title":"Peripheral differential leukocyte counts and subsequent mortality from all diseases, cancers, and cardiovascular diseases in Taiwanese","volume":"102","author":"Huang","year":"2003","journal-title":"J Formos Med Assoc"},{"key":"10.1111\/IGC.0b013e3181ef8deb_bb0095","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.ijrobp.2007.09.024","article-title":"Prognostic value of baseline lymphocyte count in cervical carcinoma treated with concurrent chemoradiation","volume":"71","author":"Choi","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1111\/IGC.0b013e3181ef8deb_bb0100","doi-asserted-by":"crossref","first-page":"122","DOI":"10.3346\/jkms.2007.22.S.S122","article-title":"Analysis of changes in the total lymphocyte and eosinophil count during immunotherapy for metastatic renal cell carcinoma: correlation with response and survival","volume":"22","author":"Jeong","year":"2007","journal-title":"J Korean Med Sci"},{"key":"10.1111\/IGC.0b013e3181ef8deb_bb0105","first-page":"5","article-title":"Ratio of neutrophil to lymphocyte counts\u2014rapid and simple parameter of systemic inflammation and stress in critically ill","volume":"102","author":"Zahorec","year":"2001","journal-title":"Bratisl Lek Listy"},{"key":"10.1111\/IGC.0b013e3181ef8deb_bb0110","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s004320050178","article-title":"The ratio of neutrophils to lymphocytes and the phenotypes of neutrophils in patients with early gastric cancer","volume":"124","author":"Hirashima","year":"1998","journal-title":"J Cancer Res Clin Oncol"},{"key":"10.1111\/IGC.0b013e3181ef8deb_bb0115","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1159\/000127412","article-title":"The baseline ratio of neutrophils to lymphocytes is associated with patient prognosis in advanced gastric cancer","volume":"73","author":"Yamanaka","year":"2007","journal-title":"Oncology"},{"key":"10.1111\/IGC.0b013e3181ef8deb_bb0120","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.ejso.2007.02.014","article-title":"Elevated preoperative neutrophil to lymphocyte ratio predicts survival following hepatic resection for colorectal liver metastasis","volume":"34","author":"Halazun","year":"2008","journal-title":"Eur J Surg Oncol"},{"key":"10.1111\/IGC.0b013e3181ef8deb_bb0125","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.ijsu.2006.05.013","article-title":"Post-operative neutrophil-lymphocyte ratio predicts complications following colorectal surgery","volume":"5","author":"Cook","year":"2007","journal-title":"Int J Surg"},{"key":"10.1111\/IGC.0b013e3181ef8deb_bb0130","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s00262-008-0516-3","article-title":"Pre-treatment neutrophil to lymphocyte ratio is elevated in epithelial ovarian cancer and predicts survival after treatment","volume":"58","author":"Cho","year":"2009","journal-title":"Cancer Immunol Immunother"},{"key":"10.1111\/IGC.0b013e3181ef8deb_bb0135","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1093\/jjco\/hym094","article-title":"Granulocyte colony-stimulating factor production and rapid progression of gastric cancer after histological change in the tumor","volume":"37","author":"Yamano","year":"2007","journal-title":"Jpn J Clin Oncol"},{"key":"10.1111\/IGC.0b013e3181ef8deb_bb0140","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s00595-007-3636-z","article-title":"Granulocyte colony-stimulating factor-producing pancreatic cancer: report of a case","volume":"38","author":"Takami","year":"2008","journal-title":"Surg Today"},{"key":"10.1111\/IGC.0b013e3181ef8deb_bb0145","doi-asserted-by":"crossref","first-page":"275","DOI":"10.2169\/internalmedicine.47.0155","article-title":"Primary pulmonary squamous cell carcinoma associated with elevated IL-6, leukocytosis, hypercalcemia, phagocytosis, reactive lymphadenopathy and glomerular mesangial cell proliferation via the production of PTH-rP and G-CSF","volume":"47","author":"Takaoka","year":"2008","journal-title":"Intern Med"},{"key":"10.1111\/IGC.0b013e3181ef8deb_bb0150","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/S0929-6646(09)60138-8","article-title":"Renal cell carcinoma producing granulocyte colony-stimulating factor","volume":"105","author":"Wang","year":"2006","journal-title":"J Formos Med Assoc"},{"key":"10.1111\/IGC.0b013e3181ef8deb_bb0155","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1097\/01.AOG.0000141552.87313.c8","article-title":"Squamous cell carcinoma of the cervix producing granulocyte colony-stimulating factor","volume":"104","author":"Nasu","year":"2004","journal-title":"Obstet Gynecol"},{"key":"10.1111\/IGC.0b013e3181ef8deb_bb0160","first-page":"2053","article-title":"Leukocytosis: basics of clinical assessment","volume":"62","author":"Abramson","year":"2000","journal-title":"Am Fam Physician"},{"key":"10.1111\/IGC.0b013e3181ef8deb_bb0165","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1007\/s00262-007-0343-y","article-title":"Dynamic cross-talk between tumor and immune cells in orchestrating the immunosuppressive network at the tumor microenvironment","volume":"56","author":"Croci","year":"2007","journal-title":"Cancer Immunol Immunother"}],"container-title":["International Journal of Gynecological Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2FIGC.0b013e3181ef8deb","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1048891X24037307?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1048891X24037307?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T12:35:07Z","timestamp":1753101307000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1048891X24037307"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10]]},"references-count":33,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2010,10]]}},"alternative-id":["S1048891X24037307"],"URL":"https:\/\/doi.org\/10.1111\/igc.0b013e3181ef8deb","relation":{},"ISSN":["1048-891X"],"issn-type":[{"value":"1048-891X","type":"print"}],"subject":[],"published":{"date-parts":[[2010,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Systemic Leukocyte Alterations Are Associated With Invasive Uterine Cervical Cancer","name":"articletitle","label":"Article Title"},{"value":"International Journal of Gynecological Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1111\/IGC.0b013e3181ef8deb","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 by IGCS and ESGO","name":"copyright","label":"Copyright"}]}}