{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T15:13:14Z","timestamp":1785597194353,"version":"3.56.0"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T00:00:00Z","timestamp":1615161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Clinical Practice"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the prognostic significance of intraductal carcinoma of the prostate (IDC\u2010P) in radical prostatectomy (RP) specimens and predictive value of IDC\u2010P for biochemical recurrence and adjuvant therapy decision.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We retrospectively evaluated patients who were performed RP between 2000 and 2014. Among, 67 patients who had stage pT3a tumour with negative surgical margin (Group 1, n\u00a0=\u00a035) and who had stage pT2 tumour with positive surgical margin (Group 2, n\u00a0=\u00a032) were included in the study. RP specimens were re\u2010evaluated for the presence of IDC\u2010P component and other prognostic factors. In both the groups, prognostic factors were compared according to the presence of IDC\u2010P and biochemical recurrence status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In Group 1, IDC\u2010P was detected in five cases and biochemical recurrence was detected in three cases. Patients with IDC\u2010P showed significantly higher biochemical recurrence than those without IDC\u2010P (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.002). In univariate analysis, IDC\u2010P was found to be significantly associated with worse progression\u2010free survival (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). In Group 2, IDC\u2010P was detected in four cases and biochemical recurrence was detected in 10 cases. Also, tumour volume was significantly higher in patients with IDC\u2010P than those without IDC\u2010P (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.02). IDC\u2010P was also significantly associated with worse progression\u2010free survival in Group 2 (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.033).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In both the groups, IDC\u2010P was a prognostic factor for progression\u2010free survival and\/or biochemical recurrence. Especially in these patients, the presence of IDC\u2010P might be helpful for postoperative adjuvant therapy management decision.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijcp.14099","type":"journal-article","created":{"date-parts":[[2021,2,23]],"date-time":"2021-02-23T07:13:27Z","timestamp":1614064407000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Prognostic value of intraductal carcinoma for adjuvant radiotherapy candidates after radical prostatectomy"],"prefix":"10.1155","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4725-488X","authenticated-orcid":false,"given":"Sedat","family":"Karakoc","sequence":"first","affiliation":[{"name":"Department of Urology Dokuz Eylul University Hospital Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serdar","family":"Celik","sequence":"additional","affiliation":[{"name":"Department of Urology Dokuz Eylul University Hospital Izmir 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