{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T20:40:56Z","timestamp":1770237656969,"version":"3.49.0"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,3,13]],"date-time":"2021-03-13T00:00:00Z","timestamp":1615593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004366","name":"Tabriz University of Medical Sciences","doi-asserted-by":"publisher","award":["65204"],"award-info":[{"award-number":["65204"]}],"id":[{"id":"10.13039\/501100004366","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Clinical Practice"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Controversy exists regarding the drug selection in hypertension (HTN) management in patients with COVID\u201019. This study aimed to compare the effects of losartan and amlodipine in patients with primary HTN and COVID\u201019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this randomised clinical trial, hospitalised patients with COVID\u201019 and primary HTN were enrolled in the study. One arm received losartan, 25\u00a0mg, twice a day and the other arm received amlodipine, 5\u00a0mg per day for 2\u00a0weeks. The main outcomes were compare 30\u2010day mortality rate and length of hospital stay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age of patients treated with losartan (N\u00a0=\u00a041) and amlodipine (N\u00a0=\u00a039) was 67.3\u00a0\u00b1\u00a014.8 and 60.1\u00a0\u00b1\u00a017.3\u00a0years, respectively (<jats:italic>P<\/jats:italic> value\u00a0=\u00a0.068). The length of hospital stay in losartan and amlodipine groups was 4.57\u00a0\u00b1\u00a02.59 and 7.30\u00a0\u00b1\u00a08.70\u00a0days, respectively (<jats:italic>P<\/jats:italic> value\u00a0=\u00a0.085). Also, the length of ICU admission in losartan and amlodipine group was 7.13\u00a0\u00b1\u00a05.99 and 7.15\u00a0\u00b1\u00a09.95\u00a0days, respectively (<jats:italic>P<\/jats:italic> value\u00a0=\u00a0.994). The 30\u2010day mortality was two and five patients in losartan and amlodipine groups, respectively (<jats:italic>P<\/jats:italic> value\u00a0=\u00a0.241).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There was no priority in losartan or amlodipine administration in COVID\u201019 patients with primary HTN in decreasing mortality rate, hospital and ICU length stay. Further studies need to clarify the first\u2010line anti\u2010HTN medications in COVID\u201019.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijcp.14124","type":"journal-article","created":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T07:08:00Z","timestamp":1614668880000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Comparison of losartan and amlodipine effects on the outcomes of patient with COVID\u201019 and primary hypertension: A randomised clinical trial"],"prefix":"10.1155","volume":"75","author":[{"given":"Masoud","family":"Nouri\u2010Vaskeh","sequence":"first","affiliation":[{"name":"Immunology Research Center Tabriz University of Medical Sciences Tabriz Iran"},{"name":"Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA) Universal Scientific Education and Research Network (USERN) Tehran 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