{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T15:19:32Z","timestamp":1784819972137,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,6,20]],"date-time":"2013-06-20T00:00:00Z","timestamp":1371686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title><jats:bold>Abstract<\/jats:bold><\/jats:title><jats:p>Nicotinamide and clindamycin gels are two popular topical medications for acne vulgaris. This study aimed to compare efficacy of the topical 4% nicotinamide and 1% clindamycin gels in these patients. In this randomized, double\u2010blind clinical trial, patients with moderate inflammatory facial acne vulgaris were randomly allocated to receive either topical 4% nicotinamide (<jats:italic>n<\/jats:italic>\u00a0=\u00a040) or 1% clindamycin gels (<jats:italic>n<\/jats:italic>\u00a0=\u00a040) twice daily. In each group, they were further categorized in two subgroups with oily and non\u2010oily types of facial skin. The Cook's acne grade was determined at baseline and at weeks 4 and 8 post treatment. Acne grade decreased from an average of 5.93\u00a0\u00b1\u00a00.83 at baseline to 4.03\u00a0\u00b1\u00a01.33 at week 4 and 2.08\u00a0\u00b1\u00a01.59 at week 8 in nicotinamide receivers, and from an average of 5.70\u00a0\u00b1\u00a00.94 at baseline to 3.85\u00a0\u00b1\u00a01.66 at week 4 and 2.03\u00a0\u00b1\u00a01.53 at week 8 in the clindamycin group (within\u2010group <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001, between\u2010group <jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05). Comparing with each other, nicotinamide and clindamycin gels were significantly more efficacious in oily and non\u2010oily skin types, respectively. No major side effect was encountered by any patient. Skin type is a significant factor in choosing between topical nicotinamide and clindamycin in patients with acne vulgaris.<\/jats:p>","DOI":"10.1111\/ijd.12002","type":"journal-article","created":{"date-parts":[[2013,6,21]],"date-time":"2013-06-21T02:49:29Z","timestamp":1371782969000},"page":"999-1004","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["Topical 4% nicotinamide vs. 1% clindamycin in moderate inflammatory acne vulgaris"],"prefix":"10.1111","volume":"52","author":[{"given":"Effat","family":"Khodaeiani","sequence":"first","affiliation":[{"name":"Department of Dermatology Sina Hospital Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohollah Fadaei","family":"Fouladi","sequence":"additional","affiliation":[{"name":"Medical Faculty Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Amirnia","sequence":"additional","affiliation":[{"name":"Department of Dermatology Sina Hospital Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majid","family":"Saeidi","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Sari University of Medical Sciences Sari Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elham Razagh","family":"Karimi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Sina Hospital Tabriz 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