{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T01:05:39Z","timestamp":1768439139840,"version":"3.49.0"},"reference-count":11,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,10,29]],"date-time":"2013-10-29T00:00:00Z","timestamp":1383004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Capillary malformation\u2013arteriovenous malformation (<jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">AVM<\/jats:styled-content>) is a recently described autosomal dominant disorder that results from mutations in <jats:italic><jats:styled-content style=\"fixed-case\">RASA<\/jats:styled-content>1<\/jats:italic>. It has been initially described as multiple <jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content>s affecting several members of the same family, associated with fast\u2010flow malformations in at least one family member.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To report and analyze clinical data on 45 patients with <jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">AVM<\/jats:styled-content> assessed at the Department of Pediatric Dermatology, Ramos Mej\u00eda Hospital (Buenos Aires, Argentina).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Retrospective clinical review of all the patients clinically diagnosed as having <jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">AVM<\/jats:styled-content> over a period of eight\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010five patients were recorded (24 females and 21 males). The age ranged from one\u00a0month to 44\u00a0years. In 36 patients, the stains were congenital; progressive acquired lesions were observed in 39. Family history was positive in 32 subjects. Well defined, round to oval, pink\u2013purple or reddish\u2010brown macules were found in all the patients; pinpoint red lesions with a pale halo were found in nine cases. The macules were warmer than normal skin in 15 cases and surrounded by a white halo in 26 cases. Three subjects presented associated overgrowth, lymphatic malformation was present in one case, retinal vascular lesion in one patient, and isolated port wine stain in two cases. Three patients also had infantile hemangioma. We had no cases of fast\u2010flow vascular malformation or combined vascular syndromes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">AVM<\/jats:styled-content> is a heterogeneous disorder with phenotypic variability, from fast\u2010flow malformation, limb enlargement, or Parkes Weber syndrome to multiple <jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content>s without internal involvement.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.12040","type":"journal-article","created":{"date-parts":[[2013,10,29]],"date-time":"2013-10-29T08:55:47Z","timestamp":1383036947000},"page":"458-461","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Capillary malformation\u2013arteriovenous malformation: a clinical review of 45 patients"],"prefix":"10.1111","volume":"53","author":[{"given":"Margarita","family":"Larralde","sequence":"first","affiliation":[{"name":"Pediatric Dermatology Department Hospital Ramos Mej\u00eda Buenos Aires Argentina"},{"name":"Dermatology Department Hospital Alem\u00e1n Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Eugenia","family":"Abad","sequence":"additional","affiliation":[{"name":"Pediatric Dermatology Department Hospital Ramos Mej\u00eda Buenos Aires Argentina"},{"name":"Dermatology Department Hospital Alem\u00e1n Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula Carolina","family":"Luna","sequence":"additional","affiliation":[{"name":"Pediatric Dermatology Department Hospital Ramos Mej\u00eda Buenos Aires Argentina"},{"name":"Dermatology Department Hospital Alem\u00e1n Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana Viktoria","family":"Hoffner","sequence":"additional","affiliation":[{"name":"Dermatology Department Hospital Universitario Virgen Macarena Sevilla Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,10,29]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/379793"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08493.x"},{"key":"e_1_2_5_4_1","first-page":"322","volume-title":"Hurwitz Clinical Pediatric Dermatology: A Textbook of Skin Disorders of Childhood and Adolescence","author":"Paller AS","year":"2006"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anplas.2006.07.002"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.20746"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-008-0842-5"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2005.03.004"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2012.01.009"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A1255"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A1907"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2011.11.008"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fijd.12040","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.12040","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T16:29:42Z","timestamp":1696350582000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.12040"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,29]]},"references-count":11,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["10.1111\/ijd.12040"],"URL":"https:\/\/doi.org\/10.1111\/ijd.12040","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,29]]},"assertion":[{"value":"2013-10-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}