{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T05:42:04Z","timestamp":1696398124496},"reference-count":40,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,6,20]],"date-time":"2013-06-20T00:00:00Z","timestamp":1371686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Normal lipid metabolism and functioning of the peroxisome proliferator\u2010activated receptor gamma (<jats:styled-content style=\"fixed-case\">PPAR<\/jats:styled-content>\u2010gamma) in the sebaceous gland is critical to maintaining a normal hair follicle. Human immunodeficiency virus (<jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>) infection affects lipid metabolism; some have hypothesized a link between <jats:styled-content style=\"fixed-case\">PPAR<\/jats:styled-content>\u2010gamma function and lipodystrophy in <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> infection. Our objective was to determine whether lipodystrophy is associated with altered hair characteristics in <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010infected women from the Women's Interagency <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> Study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Hair characteristics and scalp inflammation were assessed by an interviewer\u2010administered questionnaire. Central lipohypertrophy and peripheral lipoatrophy were defined by self\u2010report of moderate to severe fat gain in central body sites and fat loss in peripheral body sites, respectively confirmed by clinical examination. Additional covariates considered in the analyses included demographics, behavioral characteristics, medical history, and <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010related factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 1037 women with data on all study variables; 76 women reported central lipohypertrophy, while only four women reported lipoatrophy. Women with central lipohypertrophy were more likely to be older, had a self\u2010reported history of injection drug use, statin medication use, diabetes, elevated cholesterol, and have self\u2010reported less hair and shorter eyelashes. After adjustment for age, central lipohypertrophy was associated with shorter eyelashes (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 2.3; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.4\u20133.8).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Central lipohypertrophy was not associated with change in scalp hair texture or scalp inflammation in this cohort. Rather, we found an association between central lipohypertrophy and shorter eyelash length. This finding may be explained by an influence of prostaglandin E<jats:sub>2<\/jats:sub> mediators on eyelash follicles.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.12044","type":"journal-article","created":{"date-parts":[[2013,6,21]],"date-time":"2013-06-21T02:48:22Z","timestamp":1371782902000},"update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Investigating the effects of metabolic dysregulation on hair follicles: a comparison of <scp>HIV<\/scp>\u2010infected women with and without central lipohypertrophy"],"prefix":"10.1111","volume":"53","author":[{"given":"Paradi","family":"Mirmirani","sequence":"first","affiliation":[{"name":"Department of Dermatology The Permanente Medical Group Vallejo CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toby","family":"Maurer","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of California San Francisco CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mardge","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Medicine Rush Medical College and Cook County Health and Hospitals System Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gypsymber","family":"D'Souza","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Johns Hopkins Bloomberg School of Public Health Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roksana","family":"Karim","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Preventative Medicine University of Southern California California CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Plankey","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Georgetown University Medical Center Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther","family":"Robison","sequence":"additional","affiliation":[{"name":"Department of Medicine Montifiore Medical Center Bronx NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anjali","family":"Sharma","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases SUNY Downstate Medical Center Brooklyn NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phyllis C.","family":"Tien","sequence":"additional","affiliation":[{"name":"Department of Medicine University of California San Francisco CA USA"},{"name":"Department of Veterans Affairs Medical Center San Francisco CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy A.","family":"Hessol","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy &amp; Medicine University of California San Francisco CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,6,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(93)70223-G"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8635(05)70310-7"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.139.1.105"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2010.01522.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2009.10.017"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2010.01519.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003122"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.442"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0038449"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.52"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.369"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.05532.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1089\/088922203771881248"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200308150-00004"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-143-5-200509060-00009"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/CDLI.12.9.1013-1019.2005"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-199803000-00004"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/154.6.563"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2008.1337"},{"key":"e_1_2_6_21_1","unstructured":"DHHS Panel on Antiretroviral Guidelines for Adults and Adolescents.Guidelines for the Use of Antiretroviral Agents in HIV\u20101\u2010Infected Adults and Adolescents. 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