{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T23:52:04Z","timestamp":1778802724372,"version":"3.51.4"},"reference-count":47,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,7,8]],"date-time":"2013-07-08T00:00:00Z","timestamp":1373241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Several studies have indicated that recurrent aphthous stomatitis (<jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content>) is associated with oxidative stress. The aim of this study was to investigate serum paraoxonase (<jats:styled-content style=\"fixed-case\">PON<\/jats:styled-content>) activity and oxidant\/antioxidant status in patients with <jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and methods<\/jats:title><jats:p>Thirty\u2010one patients with <jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content> and 31 healthy controls were enrolled. Serum <jats:styled-content style=\"fixed-case\">PON<\/jats:styled-content>1 and arylesterase activities, total antioxidant capacity, total oxidant status, and oxidative stress index were determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Serum total antioxidant capacity levels, <jats:styled-content style=\"fixed-case\">PON<\/jats:styled-content>1, and arylesterase activities were significantly lower in <jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content> than controls (<jats:italic>P\u00a0&lt;\u00a0<\/jats:italic>0.001), while total oxidant status levels and\u00a0oxidative stress index were significantly higher (<jats:italic>P\u00a0&lt;\u00a0<\/jats:italic>0.001). <jats:styled-content style=\"fixed-case\">PON<\/jats:styled-content>1 activity had a significant correlation with high\u2010density lipoprotein cholesterol only (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.482, <jats:italic>P\u00a0&lt;\u00a0<\/jats:italic>0.05),\u00a0while there were no correlations with other lipids (<jats:italic>P\u00a0<\/jats:italic>&gt;\u00a00.05) in patients with <jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results indicate that <jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content> is associated with decreased <jats:styled-content style=\"fixed-case\">PON<\/jats:styled-content>1 activity and increased oxidative stress that plays a crucial role in the pathogenesis of <jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content>. Further studies on a larger number of patients are needed to verify these results.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.12084","type":"journal-article","created":{"date-parts":[[2013,7,8]],"date-time":"2013-07-08T08:32:41Z","timestamp":1373272361000},"page":"1259-1264","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Assessment of the serum paraoxonase activity and oxidant\/antioxidant status in patients with recurrent aphthous stomatitis"],"prefix":"10.1111","volume":"52","author":[{"given":"Serap Gunes","family":"Bilgili","sequence":"first","affiliation":[{"name":"Departments of Dermatology Faculty of Medicine Yuzuncu Yil University Van Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Halil","family":"Ozkol","sequence":"additional","affiliation":[{"name":"Medical Biology Faculty of Medicine Yuzuncu Yil University  Van 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