{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T07:28:17Z","timestamp":1781249297750,"version":"3.54.1"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,2,14]],"date-time":"2014-02-14T00:00:00Z","timestamp":1392336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Progressive hemifacial atrophy or Parry\u2013Romberg Syndrome (<jats:styled-content style=\"fixed-case\">PRS<\/jats:styled-content>) is a rare, acquired, progressive dysplasia of subcutaneous tissue and bone characterized by unilateral facial involvement. Its etiology is unknown, but theories about its pathogenesis include infectious, degenerative, autoimmune, and traumatic causes among others. The causal relationship of <jats:styled-content style=\"fixed-case\">PRS<\/jats:styled-content> and linear morphea <jats:italic>en coup de sabre<\/jats:italic> (<jats:styled-content style=\"fixed-case\">LMCS<\/jats:styled-content>) with <jats:italic>Borrelia burgdorferi<\/jats:italic> infection remains controversial. Our goal was to serologically determine anti\u2010<jats:italic>B.\u00a0burgdorferi<\/jats:italic> antibodies in patients diagnosed with <jats:styled-content style=\"fixed-case\">PRS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">LMCS<\/jats:styled-content> to establish a possible association as a causative agent.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a serology study with patients belonging to a group of 21 individuals diagnosed with <jats:styled-content style=\"fixed-case\">PRS<\/jats:styled-content>, six with <jats:styled-content style=\"fixed-case\">LMCS<\/jats:styled-content>, and 21 matched controls. Anti\u2010<jats:italic>Borrelia <\/jats:italic><jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content> antibodies were determined by <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>. A descriptive statistical analysis and Fischer's exact test were done.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In serological tests, only two cases had borderline values and were further analyzed by Western blot with non\u2010confirmatory results. For both the <jats:styled-content style=\"fixed-case\">PRS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">LMCS<\/jats:styled-content> group, the association test was not significant, suggesting a lack of association between <jats:styled-content style=\"fixed-case\">PRS<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">LMCS<\/jats:styled-content> and the presence of anti\u2010<jats:italic>Borrelia<\/jats:italic> antibodies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In Mexico there are no previous studies on <jats:italic>Borrelia<\/jats:italic> infection and its relationship between <jats:styled-content style=\"fixed-case\">PRS<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">LMCS<\/jats:styled-content>. Our result showed a lack of association of either clinical entities with anti\u2010<jats:italic>Borrelia<\/jats:italic>\u2010antibodies. Former reports of this association may suggest coincidental findings without causal relationship.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.12105","type":"journal-article","created":{"date-parts":[[2014,2,17]],"date-time":"2014-02-17T07:35:21Z","timestamp":1392622521000},"page":"947-951","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Lack of <scp>I<\/scp>g<scp>G<\/scp> antibody seropositivity to <i><scp>B<\/scp>orrelia burgdorferi<\/i> in patients with <scp>P<\/scp>arry\u2013<scp>R<\/scp>omberg syndrome and linear morphea <i>en coup de sabre<\/i> in <scp>M<\/scp>exico"],"prefix":"10.1111","volume":"53","author":[{"given":"Claudia","family":"Guti\u00e9rrez\u2010G\u00f3mez","sequence":"first","affiliation":[{"name":"Graduate Studies Division, Plastic and Reconstructive Surgery Universidad Nacional Aut\u00f3noma de M\u00e9xico and General Hospital \u201cDr. Manuel Gea Gonz\u00e1lez\u201d Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana L.","family":"God\u00ednez\u2010Hana","sequence":"additional","affiliation":[{"name":"Center for Research and Development in Health Sciences (CIDICS) Universidad Aut\u00f3noma de Nuevo Le\u00f3n (UANL) Monterrey Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisela","family":"Garc\u00eda\u2010Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Center for Research and Development in Health Sciences (CIDICS) Universidad Aut\u00f3noma de Nuevo Le\u00f3n (UANL) Monterrey Mexico"},{"name":"Biochemistry and Molecular Medicine Department School of Medicine, Universidad Aut\u00f3noma de Nuevo Le\u00f3n (UANL) Monterrey Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda de Lourdes","family":"Su\u00e1rez\u2010Roa","sequence":"additional","affiliation":[{"name":"Research Service General Hospital \u201cDr. Manuel Gea Gonz\u00e1lez\u201d Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Toussaint\u2010Caire","sequence":"additional","affiliation":[{"name":"Dermatology Service General Hospital \u201cDr. Manuel Gea Gonz\u00e1lez\u201d Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Vega\u2010Memije","sequence":"additional","affiliation":[{"name":"Dermatology Service General Hospital \u201cDr. Manuel Gea Gonz\u00e1lez\u201d Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Guti\u00e9rrez\u2010Mendoza","sequence":"additional","affiliation":[{"name":"Dermatology Service General Hospital \u201cDr. Manuel Gea Gonz\u00e1lez\u201d Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcia","family":"P\u00e9rez\u2010Dosal","sequence":"additional","affiliation":[{"name":"Graduate Studies Division, Plastic and Reconstructive Surgery Universidad Nacional Aut\u00f3noma de M\u00e9xico and General Hospital \u201cDr. Manuel Gea Gonz\u00e1lez\u201d Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos E.","family":"Medina\u2010De la Garza","sequence":"additional","affiliation":[{"name":"Center for Research and Development in Health Sciences (CIDICS) Universidad Aut\u00f3noma de Nuevo Le\u00f3n (UANL) Monterrey Mexico"},{"name":"Immunology Department School of Medicine and University Hospital \u201cDr. Jos\u00e9 E. 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