{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T06:34:08Z","timestamp":1722407648081},"reference-count":29,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,10,18]],"date-time":"2013-10-18T00:00:00Z","timestamp":1382054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2013,12]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>AIDS<\/jats:styled-content>\u2010related K<\/jats:styled-content>aposi's sarcoma (KS<\/jats:styled-content>) is a unique model of the relationship between viral infection, immunity, environmental, and genetic factors in viral cancers. The goal was to determine the distribution of KS<\/jats:styled-content> cases among B<\/jats:styled-content>razilian geopolitical regions, looking at the ecological relationship with median CD<\/jats:styled-content>4 cell count.<\/jats:p><\/jats:sec>Methods<\/jats:title>Ecological study using B<\/jats:styled-content>razilian N<\/jats:styled-content>ational D<\/jats:styled-content>iseases R<\/jats:styled-content>eporting D<\/jats:styled-content>atabases: 1982\u20132009. Subjects \u226513\u00a0years of age who have KS<\/jats:styled-content> cited in their AIDS<\/jats:styled-content> reporting form were selected, and demographic and HIV<\/jats:styled-content> exposure data were collected.<\/jats:p><\/jats:sec>Results<\/jats:title>We found 11,731 KS<\/jats:styled-content> cases in the period, with a prevalence of 2.4% among AIDS<\/jats:styled-content> cases; 88% were male, and 68% lived in the S<\/jats:styled-content>outheast region, which accounted for 59% of AIDS<\/jats:styled-content> cases. The regional and national prevalence trends were similar, although the highest proportion among women was found in the N<\/jats:styled-content>orth region, which has the lowest number of both AIDS<\/jats:styled-content> and KS<\/jats:styled-content> cases. Heterosexual transmission accounted for 87% of HIV<\/jats:styled-content> among women compared to 18% among men. Fifty\u2010seven percent of all KS<\/jats:styled-content> cases were diagnosed before antiretroviral therapy (ART<\/jats:styled-content>). Injection drug use accounted for 11% of KS<\/jats:styled-content> cases. Median survival was 472\u00a0days before the ART<\/jats:styled-content> era and 1482 after it (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.001). Median CD<\/jats:styled-content>4 counts increased in all regions in the period as ART<\/jats:styled-content> coverage expanded, and a resulting correlating decline in KS<\/jats:styled-content> cases was observed.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Prevalence of KS<\/jats:styled-content> declined after the introduction of ART<\/jats:styled-content> in all regions of B<\/jats:styled-content>razil, suggesting individual protection conveyed by ART<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.12116","type":"journal-article","created":{"date-parts":[[2013,10,18]],"date-time":"2013-10-18T07:04:12Z","timestamp":1382079852000},"page":"1525-1529","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["AIDS<\/scp>\u2010related K<\/scp>aposi's sarcoma in B<\/scp>razil: trends and geopolitical distribution"],"prefix":"10.1111","volume":"52","author":[{"given":"Val\u00e9ria","family":"Saraceni","sequence":"first","affiliation":[{"name":"Rio de Janeiro City Health Secretariat Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina C.","family":"Talhari","sequence":"additional","affiliation":[{"name":"Foundation of Tropical Medicine Amazonas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerson. 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