{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T21:52:56Z","timestamp":1772401976927,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,7,29]],"date-time":"2014-07-29T00:00:00Z","timestamp":1406592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2014,11]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Severe cutaneous adverse reactions (SCAR<\/jats:styled-content>) are rare but important causes of morbidity and mortality. Stevens\u2010Johnson syndrome (SJS<\/jats:styled-content>), T<\/jats:styled-content>oxic E<\/jats:styled-content>pidermal N<\/jats:styled-content>ecrolysis (TEN<\/jats:styled-content>), and drug reaction with eosinophilia and systemic symptoms (DRESS<\/jats:styled-content>) are severe cutaneous drug reactions that can be potentially life threatening. Our study aims to look at the epidemiology of SCAR<\/jats:styled-content> in the local setting in Singapore and the underlying characteristics of our patients that may influence the drug reaction seen.<\/jats:p><\/jats:sec>Methods<\/jats:title>Data was collected retrospectively from in\u2010patient records in the period of J<\/jats:styled-content>anuary 2007 to D<\/jats:styled-content>ecember 2011. We looked at several factors: (i) patient demographics including age, gender, ethnicity, comorbidities, (ii) culprit drug(s), (iii) latent period, (iv) drug reaction observed, (v) systemic complications, (vi) length of hospital stay, (vii) treatment given, and (viii) outcomes (mortality, morbidity).<\/jats:p><\/jats:sec>Results<\/jats:title>We collected data from 42 patients. The mean age of our patients was 51.8\u00a0years. Twenty\u2010nine (69%) of the patients had underlying comorbidities. The most common culprit drug group was antibiotics. SJS<\/jats:styled-content> was the most common SCAR<\/jats:styled-content> observed (54.8%), followed by acute generalized exanthematous pustolosis (AGEP<\/jats:styled-content>; 24%), TEN<\/jats:styled-content> (11.9%), and DRESS<\/jats:styled-content> (2%). Sixteen patients (38.1%) had complications, and there was one reported death. There was a weak correlation (correlation coefficient 0.29, P<\/jats:italic> value\u00a0=\u00a00.15, 95% CI<\/jats:styled-content>\u00a0=\u00a02.07) between early steroid therapy and the length of stay.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Antibiotics are the most common culprit drugs. The most common SCAR<\/jats:styled-content> observed in our study was SJS<\/jats:styled-content>. Early initiation of steroids may lead to a more favorable outcome.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.12118","type":"journal-article","created":{"date-parts":[[2014,7,29]],"date-time":"2014-07-29T05:14:01Z","timestamp":1406610841000},"page":"1339-1345","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Severe cutaneous adverse reactions in a local hospital setting: a 5\u2010year retrospective study"],"prefix":"10.1111","volume":"53","author":[{"given":"Peiqi","family":"Su","sequence":"first","affiliation":[{"name":"National University Hospital Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen Wee Derrick","family":"Aw","sequence":"additional","affiliation":[{"name":"National University Hospital Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,7,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"3358","DOI":"10.1001\/jama.1986.03380240052027","article-title":"Drug\u2010induced cutaneous reactions: a report from the Boston Collaborative Drug Surveillance Program on 15,438 consecutive inpatients, 1975 to 1982","volume":"256","author":"Bigby M","year":"1986","journal-title":"JAMA"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1027\/0838-1925.14.4.143"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.08.050"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08156.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1987.01660330077013"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-6-52"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2011.08.010"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.2217\/17410541.2.3.225"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199512143332404"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.090401"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200565150-00002"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.06.085"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.08.039"},{"key":"e_1_2_7_15_1","first-page":"537","article-title":"Analysis of treatment and deceased cases of severe adverse drug reactions\u2010 analysis of 46 cases of Stevens\u2010Johnson syndrome and toxic epidermal necrolysis","volume":"58","author":"Yamane Y","year":"2009","journal-title":"Arerugi"},{"key":"e_1_2_7_16_1","first-page":"767","article-title":"Thirumoorthy, et al. 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