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Several guidelines recommend <jats:styled-content style=\"fixed-case\">ECP<\/jats:styled-content> as a treatment of choice in erythrodermic primary cutaneous <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\u2010cell lymphomas (<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CTCL<\/jats:styled-content>). However, the level of evidence is low due to the rarity of this disease and the lack of randomized controlled trials. We performed a review of the English literature, restricting our analysis to studies including erythrodermic patients and more than 10 cases. Based on these criteria, we identified 28 studies, with a total of 407 patients. The median response rate in erythrodermic patients was 63% (range 31\u201386%), with a complete response rate ranging between 0 and 62% (median 20%). In our experience, we treated 51 patients with E\u2010<jats:styled-content style=\"fixed-case\">CTCL<\/jats:styled-content> since 1992. A clinical response was obtained in 32 of 51 patients (63%), with a 16% complete response rate. The median time for response induction was eight\u00a0months (range: 1\u201323). The median response duration was 22.4\u00a0months (range six months to 11 years). The treatment was generally well tolerated without systemic toxicities grade <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>\u2013<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>. The pretreatment parameters significantly associated with a higher likelihood to obtain a clinical response were the B\u2010score in the peripheral blood, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4\/<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8 ratio, and amount of circulating <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>3+<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8+ cells. Literature data together with our personal experience clearly support the clinical activity and tolerability of <jats:styled-content style=\"fixed-case\">ECP<\/jats:styled-content> in patients with E\u2010<jats:styled-content style=\"fixed-case\">CTCL<\/jats:styled-content>. Prospective controlled clinical trials are strongly recommended to better document the evidence.<\/jats:p>","DOI":"10.1111\/ijd.12121","type":"journal-article","created":{"date-parts":[[2013,6,21]],"date-time":"2013-06-21T02:48:31Z","timestamp":1371782911000},"page":"1308-1318","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Extracorporeal photopheresis for the treatment of erythrodermic cutaneous <scp>T<\/scp>\u2010cell lymphoma: a single center clinical experience with long\u2010term follow\u2010up data and a brief overview of the literature"],"prefix":"10.1111","volume":"52","author":[{"given":"Pietro","family":"Quaglino","sequence":"first","affiliation":[{"name":"Department of Medical Sciences and Human Oncology Section of Dermato\u2010Oncology University of Turin Turin 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