{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T02:46:27Z","timestamp":1780368387868,"version":"3.54.1"},"reference-count":28,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,6,25]],"date-time":"2014-06-25T00:00:00Z","timestamp":1403654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Mycosis fungoides (<jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content>) is the most frequent type of cutaneous T cell lymphoma. Its clinicopathological spectrum is wide, and the resulting diversity makes it difficult to establish a differential diagnosis among pityriasis lichenoides (<jats:styled-content style=\"fixed-case\">PL<\/jats:styled-content>), lymphomatoid papulosis (LyP), and atypical <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study describes four patients with longstanding <jats:styled-content style=\"fixed-case\">PL<\/jats:styled-content>\u2010like lesions, in whom clinicopathological correlations contributed towards the establishment of definitive diagnoses of <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The clinical histories of the four patients were reviewed. Skin biopsies were processed by hematoxylin and eosin staining and immunohistochemical techniques. Disease spread was studied according to laboratory tests, complete blood counts, biochemical parameters, lactate dehydrogenase, lymphocyte populations, and S\u00e9zary cells. Thoracoabdominopelvic computed tomography was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The four patients included two women and two men, aged 35\u201370\u00a0years, all of whom had chronic skin lesions located mainly on the trunk and extremities. In three patients, initial clinicopathological correlations led to the diagnosis of <jats:styled-content style=\"fixed-case\">PL<\/jats:styled-content>; further biopsies were required to diagnose <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content>. In all patients, the atypical lymphocytic infiltrate showed a lichenoid or perivascular distribution with focal epidermotropism and parakeratosis. All cases proved positive for <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4 and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>3, and negative for <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>20, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8, and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>30. Polymerase chain reaction showed monoclonal\u2010type T cells in one and polyclonal infiltrates in three patients. All patients were initially treated with topical corticosteroids and photochemotherapy. None of the treatments proved completely successful, but subsequent tests have yielded no evidence of disease progression in any patient.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients with clinical features of longstanding <jats:styled-content style=\"fixed-case\">PL<\/jats:styled-content> and histological findings consistent with <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content>, differential diagnosis must include <jats:styled-content style=\"fixed-case\">PL<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> L<\/jats:styled-content>y<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>, and papular <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content>. As some forms of <jats:styled-content style=\"fixed-case\">PL<\/jats:styled-content> evolve towards <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">PL<\/jats:styled-content>\u2010like forms of <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content>, these patients should undergo regular follow\u2010up and repeated biopsies in order to discard diagnoses of atypical forms of <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.12135","type":"journal-article","created":{"date-parts":[[2014,6,25]],"date-time":"2014-06-25T06:47:13Z","timestamp":1403678833000},"page":"1331-1338","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Adult pityriasis lichenoides\u2010like mycosis fungoides: a clinical variant of mycosis fungoides"],"prefix":"10.1111","volume":"53","author":[{"given":"Blanca","family":"de Unamuno Bustos","sequence":"first","affiliation":[{"name":"Department of Dermatology General Hospital of Valencia Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amparo P.","family":"Ferriols","sequence":"additional","affiliation":[{"name":"Department of Dermatology General Hospital of Valencia Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa B.","family":"S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Department of Dermatology General Hospital of Valencia Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana G.","family":"Rabasco","sequence":"additional","affiliation":[{"name":"Department of Dermatology General Hospital of Valencia Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen 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