{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T12:34:54Z","timestamp":1784637294575,"version":"3.55.0"},"reference-count":19,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,9,10]],"date-time":"2014-09-10T00:00:00Z","timestamp":1410307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Wroclaw Medical University's own research fund","award":["ST-457"],"award-info":[{"award-number":["ST-457"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Mutations in nucleotide excision repair (<jats:styled-content style=\"fixed-case\">NER<\/jats:styled-content>) genes are the cause of xeroderma pigmentosum, a genetic syndrome with proneness to basal cell carcinoma (<jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content>) of the skin. Single nucleotide polymorphisms (<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s) may affect the effectiveness of <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> repair and hence influence individual susceptibility to a variety of neoplasms. The aim of this study was to find associations between <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s in selected <jats:styled-content style=\"fixed-case\">NER<\/jats:styled-content> genes and sporadic <jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content> development.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>The study group consisted of 100 patients with histopathologically confirmed <jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content>s and the control group of 100 elderly individuals with no personal history of any cancer. <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> isolated from peripheral blood lymphocytes was genotyped for seven <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s in five different <jats:styled-content style=\"fixed-case\">NER<\/jats:styled-content> genes. Statistical analyses for associations were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A weak association between <jats:italic><jats:styled-content style=\"fixed-case\">XPD<\/jats:styled-content><\/jats:italic> exon 6 silent C\/A polymorphism and <jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content> development risk was found when comparing single polymorphisms between the two groups. When considering sex and <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s, men with the A\u2010allele in <jats:italic><jats:styled-content style=\"fixed-case\">XPC<\/jats:styled-content><\/jats:italic> intron 11 C\/A have been found to have a decreased risk of <jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There is no consistency in association studies between <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s and <jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content> susceptibility. <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s in <jats:styled-content style=\"fixed-case\">NER<\/jats:styled-content> genes seem to have an insignificant influence on the risk of developing <jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content> of the skin.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.12156","type":"journal-article","created":{"date-parts":[[2014,9,11]],"date-time":"2014-09-11T02:55:09Z","timestamp":1410404109000},"page":"1474-1477","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Polymorphisms in nucleotide excision repair genes and basal cell carcinoma of the skin"],"prefix":"10.1111","volume":"53","author":[{"given":"Karolina A.","family":"Pesz","sequence":"first","affiliation":[{"name":"Department of Genetics Wroclaw Medical University Wroclaw Poland"},{"name":"Department of Dermatology, Venerology and Allergology Wroclaw Medical University Wroclaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej","family":"Bieniek","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venerology and Allergology Wroclaw Medical University Wroclaw 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