{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T10:38:33Z","timestamp":1778755113102,"version":"3.51.4"},"reference-count":18,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,9,30]],"date-time":"2013-09-30T00:00:00Z","timestamp":1380499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Human <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> cell lymphotropic virus type I (HTLV\u2010I) is associated with specific manifestations such as adult <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> cell lymphoma\/leukemia (<jats:styled-content style=\"fixed-case\">ATLL<\/jats:styled-content>), <jats:styled-content style=\"fixed-case\">HTLV<\/jats:styled-content>\u2010I\u2010associated myelopathy\/tropical spastic paraparesis (<jats:styled-content style=\"fixed-case\">HAM<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">TSP<\/jats:styled-content>), <jats:styled-content style=\"fixed-case\">HTLV<\/jats:styled-content>\u2010I\u2010associated uveitis, and infective dermatitis associated with <jats:styled-content style=\"fixed-case\">HTLV<\/jats:styled-content>\u2010I (<jats:styled-content style=\"fixed-case\">IDH<\/jats:styled-content>). Although <jats:styled-content style=\"fixed-case\">ATLL<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">IDH<\/jats:styled-content> are considered specific manifestations of <jats:styled-content style=\"fixed-case\">HTLV<\/jats:styled-content>\u2010I infection, several dermatological manifestations have been described in <jats:styled-content style=\"fixed-case\">HTLV<\/jats:styled-content>\u2010I seropositive patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study was conducted to determine the prevalences of skin lesions in patients infected with <jats:styled-content style=\"fixed-case\">HTLV<\/jats:styled-content>\u2010I in an area of Brazil endemic for <jats:styled-content style=\"fixed-case\">HTLV<\/jats:styled-content>\u2010I infection and to compare these prevalences with those in seronegative individuals in the same region.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prevalence study was conducted between 2008 and 2010 with two groups of individuals comprising, respectively, 179 <jats:styled-content style=\"fixed-case\">HTLV<\/jats:styled-content>\u2010I seropositive (positive enzyme\u2010linked immunosorbent assay [<jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>] and positive Western blot analysis) and 193 <jats:styled-content style=\"fixed-case\">HTLV<\/jats:styled-content>\u2010I seronegative individuals (<jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>\u2010negative). The subjects were selected on a random basis and evaluated using a questionnaire to obtain epidemiological and clinical data. A physical examination was performed to verify the presence of skin lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Superficial mycoses were found in 54 (30.2%) seropositive subjects and in 26 (13.5%) of the seronegative group (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001). Xerosis was found in 39.1% of <jats:styled-content style=\"fixed-case\">HTLV<\/jats:styled-content>\u2010I infected subjects and in 9.3% of seronegative controls (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001). Ichthyosis was diagnosed in nine (5.0%) <jats:styled-content style=\"fixed-case\">HTLV<\/jats:styled-content>\u2010I seropositive subjects but in none of the control group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.001). A diagnosis of seborrheic dermatitis was made in 43 (24.0%) <jats:styled-content style=\"fixed-case\">HTLV<\/jats:styled-content>\u2010I infected subjects and in 24 (12.4%) seronegative controls (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.004). Furthermore, dermatological manifestations were more intense in the <jats:styled-content style=\"fixed-case\">HTLV<\/jats:styled-content>\u2010I seropositive group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Several dermatological manifestations are more common and more severe in <jats:styled-content style=\"fixed-case\">HTLV<\/jats:styled-content>\u2010I seropositive subjects. The presence of these manifestations in an area endemic for <jats:styled-content style=\"fixed-case\">HTLV<\/jats:styled-content>\u2010I infection may provide some clues in the investigation of this infection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.12170","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T01:50:50Z","timestamp":1381542650000},"page":"1098-1102","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Dermatological manifestations of individuals infected with human <scp>T<\/scp> cell lymphotropic virus type I (HTLV\u2010I)"],"prefix":"10.1111","volume":"53","author":[{"given":"Lorena","family":"Dantas","sequence":"first","affiliation":[{"name":"Immunology Service Federal University of Bahia (UFBA) Salvador BA Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Netto","sequence":"additional","affiliation":[{"name":"Department of Medicine Federal University of Bahia (UFBA) Salvador BA Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marshall J.","family":"Glesby","sequence":"additional","affiliation":[{"name":"Department of Medicine Weill Cornell Medical College New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edgar M.","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Immunology Service Federal University of Bahia (UFBA) Salvador BA Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo","family":"Machado","sequence":"additional","affiliation":[{"name":"Immunology Service Federal University of Bahia (UFBA) Salvador BA Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,9,30]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.12.7415"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)91452-3"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)73974-1"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(07)70081-6"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2006.0140"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2011.02.004"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2007.00456.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1998.02040.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1966.tb12181.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)92896-P"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2003.68.562"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0037-86822005000100009"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1789.2000.00320.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.112.2.e136"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200001020-00001"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1086\/380567"},{"key":"e_1_2_5_18_1","first-page":"443","volume-title":"HTLV\u20101 and the Nervous System","author":"Hashiguchi T","year":"1989"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1086\/367572"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fijd.12170","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.12170","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T18:02:57Z","timestamp":1696356177000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.12170"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9,30]]},"references-count":18,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["10.1111\/ijd.12170"],"URL":"https:\/\/doi.org\/10.1111\/ijd.12170","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,30]]},"assertion":[{"value":"2013-09-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}