{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:48:36Z","timestamp":1792100916967,"version":"4.4.0"},"reference-count":20,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,4,2]],"date-time":"2014-04-02T00:00:00Z","timestamp":1396396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"University of Damascus"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2014,12]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Pemphigus vulgaris (PV<\/jats:styled-content>) is known to be strongly associated with particular alleles of the human leukocyte antigen (HLA<\/jats:styled-content>)\u2010DRB<\/jats:styled-content>1* loci. However, to date, the association of HLA<\/jats:styled-content> with pemphigus has not been studied in a Syrian population.<\/jats:p><\/jats:sec>Objectives<\/jats:title>We aimed to study HLA<\/jats:styled-content>\u2010DRB<\/jats:styled-content>1* loci variation in Syrian PV<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>Methods<\/jats:title>We used a sequence\u2010specific primer polymerase chain reaction method to define the allele type of the DRB<\/jats:styled-content>1* loci in 91 patients with PV<\/jats:styled-content> and 270 healthy control subjects.<\/jats:p><\/jats:sec>Results<\/jats:title>We noticed an increased frequency of HLA<\/jats:styled-content>\u2010DRB<\/jats:styled-content>1*04 and DRB<\/jats:styled-content>1*14 alleles in patients with PV<\/jats:styled-content> compared with healthy control subjects (67.0% vs. 26.3%; odds ratio [OR<\/jats:styled-content>]\u00a0=\u00a05.7, corrected P\u00a0<\/jats:italic><\u00a00.0001 for DRB<\/jats:styled-content>1*04; 54.9% vs. 11.0%; OR<\/jats:styled-content>\u00a0=\u00a09.5, corrected P\u00a0<\/jats:italic><\u00a00.0001 for DRB<\/jats:styled-content>1*14). Among DRB<\/jats:styled-content>1*04\u2010positive PV<\/jats:styled-content> patients, the DRB<\/jats:styled-content>1*402 subtype was markedly increased compared with DRB<\/jats:styled-content>1*04\u2010positive healthy controls (84.3% vs. 26.7%; corrected P\u00a0<\/jats:italic>=\u00a00.002), whereas the DRB<\/jats:styled-content>1*0403 variant was represented more commonly in DRB<\/jats:styled-content>1*04\u2010positive healthy individuals than in DRB<\/jats:styled-content>1*04\u2010positive PV<\/jats:styled-content> patients (45.0% vs. 1.6%; corrected P\u00a0<\/jats:italic><\u00a00.0001). In addition, the frequency of DRB<\/jats:styled-content>1*11 was significantly decreased in PV<\/jats:styled-content> patients compared with healthy controls (19.7% vs. 50.4%; OR<\/jats:styled-content>\u00a0=\u00a00.25, corrected P\u00a0<\/jats:italic><\u00a00.0001).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The occurrence of PV<\/jats:styled-content> is positively associated with HLA<\/jats:styled-content>\u2010DRB<\/jats:styled-content>1*14 and HLA<\/jats:styled-content>\u2010DRB<\/jats:styled-content>1*0402 but negatively associated with HLA<\/jats:styled-content>\u2010DRB<\/jats:styled-content>1*11 in the Syrian population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.12184","type":"journal-article","created":{"date-parts":[[2014,4,3]],"date-time":"2014-04-03T02:13:24Z","timestamp":1396491204000},"page":"1460-1463","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Allelic variation in HLA\u2010DRB1* loci in Syrian pemphigus vulgaris patients"],"prefix":"10.1111","volume":"53","author":[{"given":"Elham","family":"Harfouch","sequence":"first","affiliation":[{"name":"Laboratory for Research and Genetic Consultation Faculty of Medicine University of Damascus Damascus Syria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saleh","family":"Daoud","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Damascus Hospital Damascus Syria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,4,2]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/08916934.2011.606444"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2011.04092.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.330"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2010.04239.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2011.03.020"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/08916930600971497"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2009.00743.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-008-9244-x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tracli.2007.10.003"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/120347540200600502"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2011.01705.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2007.00826.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2005.09.003"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1999.00626.x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2010.01057.x"},{"key":"e_1_2_5_17_1","first-page":"79","article-title":"Association between HLA\u2010DRB1, DQB1 genes and pemphigus vulgaris in Chinese Hans","volume":"20","author":"Zhou SH","year":"2003","journal-title":"Zhonghua Yi Xue Yi Chuan Xue Za Zhi"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.6.3883"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.1.635"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06882.x"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/09629350310001619735"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fijd.12184","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.12184","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T08:02:41Z","timestamp":1696406561000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.12184"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,2]]},"references-count":20,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["10.1111\/ijd.12184"],"URL":"https:\/\/doi.org\/10.1111\/ijd.12184","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,2]]},"assertion":[{"value":"2014-04-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}