{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T19:39:54Z","timestamp":1771357194037,"version":"3.50.1"},"reference-count":7,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,10,29]],"date-time":"2013-10-29T00:00:00Z","timestamp":1383004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Granuloma annulare (<jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content>) is a relatively common, self\u2010limiting condition that can be associated with disorders such as diabetes mellitus, malignancy, and thyroid disease, and with the use of some drugs. Topiramate is approved for the prevention of migraine. Its adverse effects include somnolence, fatigue, paresthesia, anorexia and weight loss, and other abnormalities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We report a 50\u2010year\u2010old woman in whom topiramate at 50\u00a0mg\/d was initiated in January 2010.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case report<\/jats:title><jats:p>One month after starting topiramate, the patient presented with painless nodules on the left ankle, which later spread to the left leg. Histopathology of a punch biopsy revealed lymphohistiocytic infiltrate, collagen degeneration, and mucin deposition, all of which are characteristic of <jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content>. Two weeks after the discontinuation of topiramate, the lesion resolved. Two years later, the patient resumed topiramate. Two weeks later, a new <jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content> appeared in the same area and disappeared within a few weeks of discontinuation of the drug.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Associations between the use of topiramate and a <jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content>\u2010like reaction have been reported in recent years. Based on the present case, it would appear that an actual association between <jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content> and topiramate is possible given that: (i) the <jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content> appeared only after the initiation of topiramate; (ii) the <jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content> resolved after the discontinuation of topiramate; (iii) the <jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content> reappeared with the resumption of topiramate in the same area and with the same characteristics as previously; and (iv) the lesion healed after topiramate was suspended.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.12189","type":"journal-article","created":{"date-parts":[[2013,10,29]],"date-time":"2013-10-29T08:57:03Z","timestamp":1383037023000},"page":"259-261","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Granuloma annulare as a possible new adverse effect of topiramate"],"prefix":"10.1111","volume":"53","author":[{"given":"Giulia","family":"Cassone","sequence":"first","affiliation":[{"name":"2nd Department of Internal Medicine Arcispedale Santa Maria Nuova Reggio Emilia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Tumiati","sequence":"additional","affiliation":[{"name":"2nd Department of Internal Medicine Arcispedale Santa Maria Nuova Reggio Emilia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,10,29]]},"reference":[{"key":"e_1_2_4_2_1","first-page":"932","article-title":"Granuloma annulare\u2010type photosensitivity disorder caused by diclofenac","volume":"119","author":"Corre Y","year":"1992","journal-title":"Ann Dermatol Venereol"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001050050264"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-0960.2002.00547.x"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.075663"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2009.03391.x"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annder.2010.11.014"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.118344"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fijd.12189","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.12189","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T21:28:08Z","timestamp":1696368488000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.12189"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,29]]},"references-count":7,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["10.1111\/ijd.12189"],"URL":"https:\/\/doi.org\/10.1111\/ijd.12189","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,29]]},"assertion":[{"value":"2013-10-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}