{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T15:39:10Z","timestamp":1762875550417},"reference-count":26,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T00:00:00Z","timestamp":1377129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title><jats:bold>Abstract<\/jats:bold><\/jats:title><jats:p>Idiopathic neck and chest wall flushing could cause disabling effects on patients' quality of life. We aimed to evaluate the effectiveness of botulinum toxin\u2010A (<jats:styled-content style=\"fixed-case\">BTA<\/jats:styled-content>) in the management of idiopathic neck and chest wall flushing. This was a pilot prospective clinical study of patients with severe idiopathic neck and anterior chest wall flushing. Two mouse units of <jats:styled-content style=\"fixed-case\">BTA<\/jats:styled-content> were injected intracutaneously with a maximum dose of 100 units per patient per session. The dermatology life quality index is used as the primary outcome measure. Twenty\u2010two patients were included in the study (18 women, four men) with an average age of 26\u00a0years (range 18\u201348). Twenty patients (90.9%) had immediate improvement with almost complete resolution of their flushing. At four\u00a0weeks follow\u2010up, 18 of 22 patients were included in the final analysis, significant improvement in quality of life was achieved, and mean baseline dermatology life quality index score 7.78 (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> 3.25) improved significantly to 4.23 (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> 3.44) with a mean difference of 3.56 (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> 4.6; 95%, confidence interval 1.27, 5.84) with paired samples <jats:italic>t<\/jats:italic>\u2010test 3.29 (d.f. 17) <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.004. <jats:styled-content style=\"fixed-case\">BTA<\/jats:styled-content> may provide an effective treatment in the management of idiopathic neck and chest wall 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