{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T02:47:50Z","timestamp":1777085270850,"version":"3.51.4"},"reference-count":21,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,7,8]],"date-time":"2013-07-08T00:00:00Z","timestamp":1373241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this study was to investigate possible associations of the five <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> polymorphic genotypes in the <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> region (transporter associated with antigen processing [<jats:styled-content style=\"fixed-case\">TAP<\/jats:styled-content>1; <jats:styled-content style=\"fixed-case\">TAP<\/jats:styled-content>1\u00a0333 a\/b, <jats:styled-content style=\"fixed-case\">TAP<\/jats:styled-content>1\u00a0637 c\/d], the <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DRB<\/jats:styled-content>1*1501\u2010rs3135388, tumor necrosis factor [<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>]\u03b1 [\u2212238 <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>] and <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>co<jats:styled-content style=\"fixed-case\">I TNF<\/jats:styled-content>\u03b2) with characteristics of family history in patients with psoriasis vulgaris.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>A total of 201 <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>zech patients with psoriasis were enrolled in the study. The patients were genotyped for the five common polymorphisms in <jats:styled-content style=\"fixed-case\">TAP<\/jats:styled-content>1, <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u03b1, and <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u03b2 genes (6p21.3) using the polymerase chain reaction\u2010restriction fragment length polymorphism\u2010based methodology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We observed significantly higher prevalence of <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>le333<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>le <jats:styled-content style=\"fixed-case\">TAP<\/jats:styled-content>1 allele in patients whose first\u2010degree relatives had a positive family history of psoriasis (<jats:italic>P<\/jats:italic><jats:sub>a<\/jats:sub>\u00a0=\u00a00.04). No differences related to family history of psoriasis were observed in <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DRB<\/jats:styled-content>1*1501 polymorphism. As for the <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u03b1 (\u2212238 <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>) polymorphism, a significant increase of the <jats:styled-content style=\"fixed-case\">GG<\/jats:styled-content> genotype was observed in patients, especially men with second\u2010 and third\u2010degree relatives with psoriasis (<jats:italic>P<\/jats:italic><jats:sub>g<\/jats:sub>\u00a0=\u00a00.008). Similarly, the <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>2<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>2 genotype of <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>co<jats:styled-content style=\"fixed-case\">I TNF<\/jats:styled-content>\u03b2 polymorphism was more frequent in psoriatic patients, especially women, whose second\u2010 and third\u2010degree relatives had psoriasis (<jats:italic>P<\/jats:italic><jats:sub>g<\/jats:sub>\u00a0=\u00a00.004). Finally, the haplotype analysis of all five polymorphisms revealed that the frequency of haplotype bc<jats:styled-content style=\"fixed-case\">CB<\/jats:styled-content>1<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> was different between not only men and women with psoriasis (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.007) but also between men and women without a family history of psoriasis (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.007).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Haplotype association of <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> gene polymorphisms with genealogy aspects of psoriasis facilitates a better understanding of etiopathogenetic aspects of the diseases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.12213","type":"journal-article","created":{"date-parts":[[2013,7,8]],"date-time":"2013-07-08T08:32:38Z","timestamp":1373272358000},"page":"960-965","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Polymorphisms in <scp>HLA<\/scp>\u2010related genes and psoriasis heredity in patients with psoriasis"],"prefix":"10.1111","volume":"52","author":[{"given":"Anna","family":"Vasku","sequence":"first","affiliation":[{"name":"Department of Pathophysiology Faculty of Medicine Masaryk University Brno Brno Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Bienertova\u2010Vasku","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology Faculty of Medicine Masaryk University Brno Brno Czech 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