{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:41:49Z","timestamp":1788309709144,"version":"build-2803163510"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,12,10]],"date-time":"2013-12-10T00:00:00Z","timestamp":1386633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>\u0391 distinct side effect of the synthetic quinolinic antimalarial drugs, still widely used for the treatment and prophylaxis of malaria, is the induction of psoriasis in predisposed or susceptible individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe two patients that had induction and exacerbation of psoriasis due to the administration of hydroxychloroquine, to adapt pertinent literature on the pathophysiology of this side effect, to review psoriasis\u2010triggered cases by newer, non\u2010quinolinic antimalarials, and to propose malaria treatment and prophylaxis guidelines for psoriatic patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>Two patients, a 40\u2010year\u2010old female with unknown history of psoriasis and a 37\u2010year\u2010old primigravida with an established history of psoriasis, were treated with hydroxychloroquine for a newly diagnosed lichen planopilaris and for an exacerbation of psoriatic arthritis, respectively. <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>ub<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ed was searched (last accessed 20 October 2012) employing as search strategy the keywords (psoriasis) <jats:styled-content style=\"fixed-case\">AND<\/jats:styled-content> (drug), where \u201cdrug\u201d is the name of each of the newer, non\u2010quinolinic antimalarials.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Psoriasis was controlled in both patients. The primigravida gave birth to a healthy child at 39\u00a0weeks of gestation. The literature review returned no articles that linked the newer antimalarials with psoriasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Despite the increased awareness, antimalarials\u2010triggered psoriasis is still diagnosed. Fortunately, the current artemisinin\u2010based antimalarial treatment can be safely offered to susceptible individuals. Additionally, prophylaxis with doxycycline or the combination atovaquone\u2013proguanil could be a safe suggestion for malaria prophylaxis in psoriatic patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.12231","type":"journal-article","created":{"date-parts":[[2013,12,10]],"date-time":"2013-12-10T08:06:49Z","timestamp":1386662809000},"page":"327-330","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Synthetic antimalarial drugs and the triggering of psoriasis \u2013 do we need disease\u2010specific guidelines for the management of patients with psoriasis at risk of malaria?"],"prefix":"10.1111","volume":"53","author":[{"given":"Agoritsa","family":"Gravani","sequence":"first","affiliation":[{"name":"Department of Dermatology University Hospital of Ioannina Ioannina Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Gaitanis","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital of Ioannina Ioannina Greece"},{"name":"Department of Skin and Venereal Diseases University of Ioannina Medical School Ioannina Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aikaterini","family":"Zioga","sequence":"additional","affiliation":[{"name":"Department of Pathology University Hospital of Ioannina Ioannina Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis D.","family":"Bassukas","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital of Ioannina Ioannina Greece"},{"name":"Department of Skin and Venereal Diseases University of Ioannina Medical School Ioannina Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,12,10]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"39","article-title":"Drug induced psoriasis","volume":"19","author":"Milavec\u2010Puretic V","year":"2011","journal-title":"Acta Dermatovenerol Croat"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2010.04570.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1963.03060130062022"},{"key":"e_1_2_6_5_1","first-page":"1516","article-title":"[Erythroderma developing in the treatment of psoriasis with antimalarials]","volume":"127","author":"Rothenborg HW","year":"1965","journal-title":"Ugeskr Laeger"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-3083.2003.00715.x"},{"key":"e_1_2_6_7_1","first-page":"671","article-title":"Exacerbation of psoriasis caused by malaria prophylaxis with chloroquine and proguanil","volume":"135","author":"Damstra RJ","year":"1991","journal-title":"Ned Tijdschr Geneeskd"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1977.01640020044007"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-4857-7_32"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.1999.00574.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12555823"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000247215"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2011.08.022"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.101766"},{"key":"e_1_2_6_15_1","unstructured":"World Health Organization:http:\/\/whqlibdoc.who.int\/publications\/2008\/9789241596756_eng.pdf"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0804595"},{"key":"e_1_2_6_17_1","volume-title":"Global Malaria Control and Elimination: Report of a Technical Review","author":"World Health Organization","year":"2008"},{"key":"e_1_2_6_18_1","unstructured":"Centre for Diseases Control Yellow Book Malaria.http:\/\/www.who.int\/mediacentre\/factsheets\/fs094\/en\/index.html"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fijd.12231","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.12231","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T12:29:17Z","timestamp":1696336157000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.12231"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,10]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.1111\/ijd.12231"],"URL":"https:\/\/doi.org\/10.1111\/ijd.12231","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,10]]},"assertion":[{"value":"2013-12-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}