{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:27:50Z","timestamp":1789172870835,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,12,30]],"date-time":"2013-12-30T00:00:00Z","timestamp":1388361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Mayo Clinic Department of Dermatology funds"},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"crossref","award":["R01 AG034676"],"award-info":[{"award-number":["R01 AG034676"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Mortality rates in patients with bullous pemphigoid (<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>) are higher than those in age\u2010matched counterparts. However, the specific causes of death in <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> subjects have not been evaluated systematically.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We sought to characterize the causes of death in patients with <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> as recorded by death certificate and to compare these with death data for age\u2010 and location\u2010matched control subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective cohort analysis conducted in a large tertiary referral center. Twenty\u2010seven participants who had a confirmed antemortem diagnosis of <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>, were residents of <jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>lmsted <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ounty, <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>innesota, and had died between January 1, 1999, and January 1, 2009, were included in the study. Underlying cause of death and multiple causes of death data for the study population were compared with data sourced from the <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>enters for <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>isease <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ontrol and <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>revention (<jats:styled-content style=\"fixed-case\">CDC<\/jats:styled-content>) for a control group matched by age and geographic location of origin by <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>nternational <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>lassification of <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>iseases, 10th <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>evision (<jats:styled-content style=\"fixed-case\">ICD<\/jats:styled-content>\u201010) block, and specific <jats:styled-content style=\"fixed-case\">ICD<\/jats:styled-content>\u201010 codes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Comparisons of specific <jats:styled-content style=\"fixed-case\">ICD<\/jats:styled-content>\u201010 codes revealed increased rates of sepsis (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.031), dementia (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.049), and major depressive disorder (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.005) in the study group. The collective incidence of <jats:styled-content style=\"fixed-case\">ICD<\/jats:styled-content>\u201010 codes for infections indicated that infections were more frequent contributors to death in the study group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.035).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Clinicians should be mindful of contributors to death in patients with <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> and might consider screening for mental health issues, educating patients on the early symptoms of sepsis, and minimizing risk factors for infection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.12243","type":"journal-article","created":{"date-parts":[[2013,12,30]],"date-time":"2013-12-30T09:56:44Z","timestamp":1388397404000},"page":"56-61","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Specific causes of death in patients with bullous pemphigoid as measured by death certificate data: a retrospective cohort study"],"prefix":"10.1111","volume":"54","author":[{"given":"Benjamin J.","family":"Barrick","sequence":"first","affiliation":[{"name":"Kansas City University of Medicine and Biosciences Kansas City MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine M.","family":"Lohse","sequence":"additional","affiliation":[{"name":"Department of Statistics Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia S.","family":"Lehman","sequence":"additional","affiliation":[{"name":"Department of Dermatology Division of Dermatopathology and Cutaneous Immunopathology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,12,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09300.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.35"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.a180"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10413.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2004.22504.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.07.022"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.141.6.691"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2010.322"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.596361"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.357"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.134.9.1075"},{"key":"e_1_2_6_13_1","unstructured":"National Center for Health Statistics.NCHS Definitions. 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