{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T12:25:05Z","timestamp":1778588705486,"version":"3.51.4"},"reference-count":12,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,12,10]],"date-time":"2013-12-10T00:00:00Z","timestamp":1386633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2014,3]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Alopecia areata (AA<\/jats:styled-content>) is a chronic disease that presents as non\u2010scarring hair loss. It is thought to be an organ\u2010specific autoimmune disease characterized by T cell infiltrates and cytokine production around anagen\u2010stage hair follicles. Interleukin\u201016 (IL<\/jats:styled-content>\u201016) is a T cell\u2010specific chemoattractant known to be associated with autoimmune disease.<\/jats:p><\/jats:sec>Objectives<\/jats:title>This study was conducted to determine whether variation in the IL<\/jats:styled-content>16<\/jats:italic> gene contributes to risk for AA<\/jats:styled-content> in the K<\/jats:styled-content>orean population.<\/jats:p><\/jats:sec>Methods<\/jats:title>A total of 270 control subjects and 229 AA<\/jats:styled-content> patients were enrolled. Genomic DNA<\/jats:styled-content> was prepared from peripheral blood. Four single nucleotide polymorphisms (SNP<\/jats:styled-content>s) (rs17875486 [promoter], rs17875491 [promoter], rs11073001 [exon], rs1803275 [exon]) of the IL<\/jats:styled-content>16<\/jats:italic> gene were selected. Genotypes were determined by direct sequencing. Sequence data were analyzed. Multiple logistic regression models were calculated.<\/jats:p><\/jats:sec>Results<\/jats:title>A significant difference emerged between the AA<\/jats:styled-content> group and the control group for one SNP<\/jats:styled-content> (rs17875491) of IL<\/jats:styled-content>16<\/jats:italic>. A further significant difference was found between patients with and without a family history of AA<\/jats:styled-content> for a second SNP<\/jats:styled-content> (rs11073001).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The present study found significant differences pertaining to two SNP<\/jats:styled-content>s of the IL<\/jats:styled-content>16<\/jats:italic> gene between, respectively, AA<\/jats:styled-content> patients and controls (rs17875491) and AA<\/jats:styled-content> patients with and without a family history of AA<\/jats:styled-content> (rs11073001). Thus, IL<\/jats:styled-content>16<\/jats:italic> polymorphisms may play a role in the pathophysiology of AA<\/jats:styled-content> or in the expression of AA<\/jats:styled-content> phenotypes. Further studies are required to elucidate the role of IL<\/jats:styled-content>\u201016 in the pathogenesis and clinical manifestation of AA<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.12251","type":"journal-article","created":{"date-parts":[[2013,12,10]],"date-time":"2013-12-10T08:16:29Z","timestamp":1386663389000},"page":"319-322","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Association between IL16<\/i><\/scp> gene polymorphisms and susceptibility to alopecia areata in the K<\/scp>orean population"],"prefix":"10.1111","volume":"53","author":[{"given":"Bark\u2010Lynn","family":"Lew","sequence":"first","affiliation":[{"name":"Department of Dermatology College of Medicine Kyunghee University Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joo\u2010Ho","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Pharmacology College of Medicine Kyunghee University Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Woo\u2010Young","family":"Sim","sequence":"additional","affiliation":[{"name":"Department of Dermatology College of Medicine Kyunghee University Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,12,10]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"crossref","first-page":"3232","DOI":"10.4049\/jimmunol.163.6.3232","article-title":"A role for IL\u201016 in the cross\u2010talk between dendritic cells and T\u00a0cells","volume":"163","author":"Kaser A","year":"1999","journal-title":"J Immunol"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/37.12.1334"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2004.09.006"},{"key":"e_1_2_5_5_1","first-page":"757","article-title":"HLA class II antigen associations help to define two types of alopecia areata","volume":"33","author":"Colombe BW","year":"1995","journal-title":"J Am Acad Dermatol"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btl268"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bth457"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0039.2002.600604.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6364191"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2012.24.1.61"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1521-6616(03)00021-4"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2003.09.012"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2009.03.016"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fijd.12251","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.12251","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T12:29:21Z","timestamp":1696336161000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.12251"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,10]]},"references-count":12,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.1111\/ijd.12251"],"URL":"https:\/\/doi.org\/10.1111\/ijd.12251","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,10]]},"assertion":[{"value":"2013-12-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}