{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T04:57:53Z","timestamp":1695790673899},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,2,14]],"date-time":"2014-02-14T00:00:00Z","timestamp":1392336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Parthenium dermatitis is a common airborne allergic health problem that induces a cell\u2010mediated hypersensitivity immune response involving activated <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> lymphocytes, which culminates in injury to the skin. The disease is manifested as itchy erythematous papules and plaques and primarily affects the exposed areas and flexures. This study aimed to identify the role of tumor necrosis factor (<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>)\u2010\u03b1 (\u2212) 308\u00a0G&gt;A polymorphism in the pathogenesis of parthenium dermatitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>A total of 120 subjects, including 60 patients exclusively diagnosed for parthenium dermatitis and 60 healthy individuals, were included in the study. The genotyping of the <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 (\u2212) 308\u00a0G&gt;A region was carried out by the amplification refractory mutational system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the present study, we demonstrated that polymorphism of the <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 (\u2013) 308 position (A and\/or G) was not statistically significant, and there was no difference in the distribution of any alleles of this locus in cases and controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The present study suggests that there is a lack of association of potent proinflammatory cytokine <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 (\u2212) 308\u00a0G&gt;A polymorphism in parthenium dermatitis in the Indian cohort. It interprets genetically endowed transcriptional capacity due to this particular single nucleotide polymorphism but does not support the prevalence of high serum levels of <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 in parthenium\u2010induced skin allergic inflammation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.12255","type":"journal-article","created":{"date-parts":[[2014,2,17]],"date-time":"2014-02-17T04:16:33Z","timestamp":1392610593000},"page":"179-184","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Genetic endowment of proinflammatory cytokine tumor necrosis factor\u2010\u03b1 (\u2013) 308 <scp>G<\/scp> &gt; A polymorphism to <i><scp>P<\/scp>arthenium hysterophorus\u2010<\/i>induced airborne contact dermatitis in an <scp>I<\/scp>ndian cohort"],"prefix":"10.1111","volume":"54","author":[{"given":"Rakesh","family":"Khatri","sequence":"first","affiliation":[{"name":"School of Environmental Sciences Jawaharlal Nehru University New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nasim","family":"Akhtar","sequence":"additional","affiliation":[{"name":"Department ofBiochemistry All India Institute of Medical Sciences New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kasturi","family":"Mukhopadhyay","sequence":"additional","affiliation":[{"name":"School of Environmental Sciences Jawaharlal Nehru University New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaushal K.","family":"Verma","sequence":"additional","affiliation":[{"name":"Department ofDermatology and Venereology All India Institute of Medical Sciences New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gomathy","family":"Sethuraman","sequence":"additional","affiliation":[{"name":"Department ofDermatology and Venereology All India Institute of Medical Sciences New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alpana","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department ofBiochemistry All India Institute of Medical Sciences New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,2,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000235067"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.44299"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01937785"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2002.460507.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1983.tb04465.x"},{"key":"e_1_2_7_7_1","first-page":"89","article-title":"Parthenium hysterophorus. 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