{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T17:12:22Z","timestamp":1722445942925},"reference-count":19,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,4,2]],"date-time":"2014-04-02T00:00:00Z","timestamp":1396396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Broadband ultraviolet <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">BB<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">UVA<\/jats:styled-content>) has been successfully used in the treatment of scleroderma, a <jats:styled-content style=\"fixed-case\">UVA<\/jats:styled-content>1\u2010responsive dermatosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the efficacy of <jats:styled-content style=\"fixed-case\">BB<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">UVA<\/jats:styled-content> versus psoralen\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">UVA<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">PUVA<\/jats:styled-content>) in psoriasis treatment and assess apoptosis as an effector mechanism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>This randomized controlled trial included 61 patients with chronic plaque psoriasis randomly divided into group <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>. Group <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content> were further randomized to either <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">IB<\/jats:styled-content> who received <jats:styled-content style=\"fixed-case\">UVA<\/jats:styled-content> 10 or 15\u00a0J\/cm<jats:sup>2<\/jats:sup> per session, respectively, while group <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> received <jats:styled-content style=\"fixed-case\">PUVA<\/jats:styled-content>. Therapy was delivered thrice weekly until clearance or 48 treatments at most. The primary outcome measured was clearance of psoriasis. Dermal lymphocytic counts and bcl\u20102 expression were measured in 20 patients from each group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>inal <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>soriasis <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>rea <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>everity <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>ndex scores were reduced within each group. The <jats:styled-content style=\"fixed-case\">UVA<\/jats:styled-content> group achieved results comparable to <jats:styled-content style=\"fixed-case\">PUVA<\/jats:styled-content> until session 24 but failed to match it at final evaluation, with significantly better clinical, immunohistochemical, and histopathological results achieved by <jats:styled-content style=\"fixed-case\">PUVA<\/jats:styled-content> (<jats:italic>P\u00a0<\/jats:italic>\u2264<jats:italic>\u00a0<\/jats:italic>0.05). Both modalities caused a reduction in dermal lymphocytic counts and epidermal bcl\u20102 expression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">BB<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">UVA<\/jats:styled-content> appears to be safe and acceptable for the treatment of chronic plaque psoriasis possibly through bcl\u20102\u2010mediated apoptosis of keratinocytes and epidermal lymphocytes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.12317","type":"journal-article","created":{"date-parts":[[2014,4,3]],"date-time":"2014-04-03T02:13:36Z","timestamp":1396491216000},"page":"1157-1164","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Broadband ultraviolet <scp>A<\/scp> in the treatment of psoriasis vulgaris: a randomized controlled trial"],"prefix":"10.1111","volume":"53","author":[{"given":"Medhat","family":"El\u2010Mofty","sequence":"first","affiliation":[{"name":"Department of Dermatology Phototherapy Unit Kasr Al Aini (PUKA) Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wedad Z.","family":"Mostafa","sequence":"additional","affiliation":[{"name":"Department of Dermatology Phototherapy Unit Kasr Al Aini (PUKA) Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Randa","family":"Yousef","sequence":"additional","affiliation":[{"name":"Department of Dermatology Phototherapy Unit Kasr Al Aini (PUKA) Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mona R. 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