{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T08:10:20Z","timestamp":1792656620914,"version":"4.5.0"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,12,10]],"date-time":"2013-12-10T00:00:00Z","timestamp":1386633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Actinic cheilitis (<jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>) is a potentially malignant disorder of the lip caused by exposure to solar radiation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study was conducted to evaluate the clinicopathologic profile of cases of <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content> and to verify associations with the degree of dysplasia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study analyzed data for 40 patients with <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>. Demographic, clinical, and histopathologic data were evaluated. Sections measuring 5\u00a0\u03bcm in thickness were cut, deparaffinized, and stained with hematoxylin and eosin for histologic examination. The degree of epithelial dysplasia was graded using the criteria defined by the World Health Organization. Two calibrated oral pathologists analyzed the slides.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Analysis of the <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content> patients sampled showed that 75.0% were male (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.002), 80.0% were aged \u226540\u00a0years (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001), 74.3% were Caucasian (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.004), and 68.6% had occupational exposure to sunlight (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.028). The most common clinical manifestation was white lesions (55.0%), and 40.0% of patients had no dysplasia. No significant associations emerged between the histologic grading of <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content> and gender (<jats:italic>P\u00a0<\/jats:italic>=\u00a01.000), age (<jats:italic>P\u00a0<\/jats:italic>=\u00a01.000), ethnicity (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.416), occupational exposure to sunlight (<jats:italic>P\u00a0<\/jats:italic>=\u00a01.000), and clinical presentation (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.467).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The degree of dysplasia in <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content> was not statistically associated with gender, age, ethnicity, occupational exposure to sunlight, or clinical appearance. This study provides some support for the hypothesis that clinicopathologic features are not related to the degree of dysplasia in <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.12332","type":"journal-article","created":{"date-parts":[[2013,12,10]],"date-time":"2013-12-10T08:14:15Z","timestamp":1386663255000},"page":"466-472","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Actinic cheilitis: clinicopathologic profile and association with degree of dysplasia"],"prefix":"10.1111","volume":"53","author":[{"given":"Dmitry Jos\u00e9","family":"de Santana Sarmento","sequence":"first","affiliation":[{"name":"Department of Dentistry State University of Para\u00edba Campina Grande Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rcia Cristina","family":"da Costa Miguel","sequence":"additional","affiliation":[{"name":"Department of 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