{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T06:43:03Z","timestamp":1777617783938,"version":"3.51.4"},"reference-count":10,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,10,29]],"date-time":"2013-10-29T00:00:00Z","timestamp":1383004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Though any drug can be a potential cause of such hypersensitivity reactions, paracetamol, an over\u2010the\u2010counter drug used extensively as an analgesic and antipyretic agent, is considered to be relatively safe, with hepatotoxicity as a major adverse effect only in large doses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>We report an instance of a severe case of <jats:styled-content style=\"fixed-case\">SJS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content> overlap syndrome in a 12\u2010year\u2010old girl, induced by three over\u2010the\u2010counter doses of 500 mg of paracetamol taken at 8\u2010hour intervals for fever.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results and discussion<\/jats:title><jats:p>Stevens\u2010Johnson Syndrome and its severe variant toxic epidermal necrolysis (<jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content>) are idiosyncratic, delayed hypersensitivity inflammatory adverse drug reactions that are associated with increased morbidity and mortality. However, treatment with antibiotics and intravenous corticosteroids along with supportive therapy improved the course of the disorder.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This case report addresses the fact that severe hypersensitivity reactions can occur with paracetamol, which can be potentially dangerous and life threatening. It is hence important for the clinicians to be alert to such severe hypersensitivity reactions even with drugs which are considered to be potentially safe such as paracetamol.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.12355","type":"journal-article","created":{"date-parts":[[2013,10,29]],"date-time":"2013-10-29T09:12:40Z","timestamp":1383037960000},"page":"1042-1044","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Paracetamol induced Stevens\u2010Johnson syndrome \u2013 toxic epidermal necrolysis overlap syndrome"],"prefix":"10.1111","volume":"53","author":[{"given":"Sasmita","family":"Biswal","sequence":"first","affiliation":[{"name":"SCB Medical College &amp; Hospital Cuttack Odisha India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swayam Sourav","family":"Sahoo","sequence":"additional","affiliation":[{"name":"SCB Medical College &amp; Hospital Cuttack Odisha India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,10,29]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1990.01670250049006"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1993.01680220104023"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1956.tb12766.x"},{"key":"e_1_2_2_5_1","first-page":"CD003676","article-title":"Paracetamol for treating fever in children","author":"Meremikwu M","year":"2002","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_2_6_1","first-page":"273","article-title":"Burn center care for patients with toxic epidermal necrolysis","volume":"180","author":"Kelemen JJ","year":"1995","journal-title":"J Am Coll Surg"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198611000-00001"},{"key":"e_1_2_2_8_1","first-page":"27","article-title":"Effectiveness of early therapy with corticosteroids in Stevens\u2010Johnson syndrome: experience with 41 cases and a hypothesis regarding pathogenesis","volume":"73","author":"Patterson R","year":"1994","journal-title":"Ann Allergy"},{"key":"e_1_2_2_9_1","first-page":"743","article-title":"High\u2010dose intravenous immunoglobulins in the treatment of Stevens Johnson syndrome and toxic epidermal necrolysis in Chinese patients: a retrospective study of 82 cases","volume":"20","author":"Chen J","year":"2010","journal-title":"Eur J Dermatol"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2005.11.012"},{"key":"e_1_2_2_11_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.090401"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fijd.12355","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.12355","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T03:20:41Z","timestamp":1696303241000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.12355"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,29]]},"references-count":10,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["10.1111\/ijd.12355"],"URL":"https:\/\/doi.org\/10.1111\/ijd.12355","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,29]]},"assertion":[{"value":"2013-10-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}