{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:30:33Z","timestamp":1761895833148},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,3,6]],"date-time":"2014-03-06T00:00:00Z","timestamp":1394064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Tuberous sclerosis is an autosomal dominant disorder with hamartomas in multiple organ systems. Facial angiofibromas (<jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>) are a common cutaneous manifestation of tuberous sclerosis. They may lead to significant cosmetic and psychological problems. Many treatment modalities have been used with variable satisfaction. Fractional photothermolysis (<jats:styled-content style=\"fixed-case\">FP<\/jats:styled-content>) is a novel concept of laser therapy, which induces non\u2010contiguous microscopic thermal injury.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study was designed to evaluate the efficacy and side effects of <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>d:<jats:styled-content style=\"fixed-case\">YAG<\/jats:styled-content> laser treatment for facial <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content> by using spot\u2010like irradiation technique similar to <jats:styled-content style=\"fixed-case\">FP<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Twelve patients (skin types III\u2013IV, aged 17\u201345\u00a0years) with facial <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content> received monthly treatment with <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>d:<jats:styled-content style=\"fixed-case\">YAG<\/jats:styled-content> laser in a pinpoint coagulation fashion. Clinical improvements were evaluated in five categories. Side effects were monitored at each follow\u2010up visit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Excellent improvement was seen in 10 patients and good improvement in two at one\u00a0month after the final treatment session. After 12\u00a0months of follow\u2010up, no patient had significant recurrence of <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>. Five patients were followed up for three\u00a0years with few pinpoint\u2010sized regrowth occurring; none of these patients received additional treatments. Side effects included transient erythema and edema in each patient but no bleeding, infection, dyspigmentation, or scarring.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The present study indicates that <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>d:<jats:styled-content style=\"fixed-case\">YAG<\/jats:styled-content> laser is an effective and safe management for the fractional treatment of facial <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.12384","type":"journal-article","created":{"date-parts":[[2014,3,7]],"date-time":"2014-03-07T04:17:41Z","timestamp":1394165861000},"page":"638-642","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Nd:<scp>YAG<\/scp> laser for \u201cfractional\u201d treatment of angiofibromas"],"prefix":"10.1111","volume":"53","author":[{"given":"Gang","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Shanghai Ninth People's Hospital Shanghai Jiaotong University School of Medicine Shanghai China"},{"name":"Department of Cosmetic Laser Center Shanghai Ninth People's Hospital Shanghai Jiaotong University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pinru","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Shanghai Ninth People's Hospital Shanghai Jiaotong University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoxi","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Shanghai Ninth People's Hospital Shanghai Jiaotong University School of Medicine Shanghai China"},{"name":"Department of Cosmetic Laser 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