{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:29:58Z","timestamp":1770823798143,"version":"3.50.1"},"reference-count":58,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,4,2]],"date-time":"2014-04-02T00:00:00Z","timestamp":1396396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Ocular melanoma is a rare subtype of melanoma, which includes uveal melanoma (<jats:styled-content style=\"fixed-case\">UM<\/jats:styled-content>) and conjunctival melanoma.<jats:styled-content style=\"fixed-case\">UM<\/jats:styled-content>is associated with an increased risk of cutaneous melanoma (<jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content>) in addition to mesothelioma, skin lesions such as epithelioid atypical Spitz tumors, and other internal malignancies due to a germline mutation of the<jats:styled-content style=\"fixed-case\">BRCA<\/jats:styled-content>1\u2010associated protein 1 (<jats:italic><jats:styled-content style=\"fixed-case\">BAP<\/jats:styled-content>1<\/jats:italic>) gene. Such familial risks are important for dermatologists to recognize when screening patients with a history of<jats:styled-content style=\"fixed-case\">UM<\/jats:styled-content>for<jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content>and other malignancies. Molecular genetics further help to elucidate the connections between<jats:styled-content style=\"fixed-case\">UM<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content>by revealing similarities and differences in important mutations among the melanoma subtypes. Both<jats:styled-content style=\"fixed-case\">UM<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content>have been shown to harbor germline mutation of<jats:italic><jats:styled-content style=\"fixed-case\">BAP<\/jats:styled-content>1<\/jats:italic>. However, somatic mutations in either<jats:italic><jats:styled-content style=\"fixed-case\">GNAQ<\/jats:styled-content><\/jats:italic>or<jats:italic><jats:styled-content style=\"fixed-case\">GNA<\/jats:styled-content>11<\/jats:italic>are unique to<jats:styled-content style=\"fixed-case\">UM<\/jats:styled-content>tumors and could be used as potential markers to differentiate<jats:styled-content style=\"fixed-case\">UM<\/jats:styled-content>from metastatic<jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content>and act as direct therapeutic targets. However,<jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content>\u2010associated<jats:italic><jats:styled-content style=\"fixed-case\">BRAF<\/jats:styled-content><\/jats:italic>and<jats:italic><jats:styled-content style=\"fixed-case\">CDKN<\/jats:styled-content>2A<\/jats:italic>mutations are rare in<jats:styled-content style=\"fixed-case\">UM<\/jats:styled-content>. This review addresses the clinical features, pathogenesis, and current treatment options of<jats:styled-content style=\"fixed-case\">UM<\/jats:styled-content>, focusing on<jats:styled-content style=\"fixed-case\">UM<\/jats:styled-content>and the<jats:italic><jats:styled-content style=\"fixed-case\">BAP<\/jats:styled-content>1<\/jats:italic>cancer syndrome to raise awareness of ocular melanoma and its greater role in the predisposition to a hereditary cancer syndrome.<\/jats:p>","DOI":"10.1111\/ijd.12386","type":"journal-article","created":{"date-parts":[[2014,4,3]],"date-time":"2014-04-03T02:14:11Z","timestamp":1396491251000},"page":"657-663","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Ocular melanoma and the<scp>BAP<\/scp>1 hereditary cancer syndrome: implications for the dermatologist"],"prefix":"10.1111","volume":"53","author":[{"given":"Lisa 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