{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:50:23Z","timestamp":1787503823511,"version":"build-2736575974"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,11,27]],"date-time":"2014-11-27T00:00:00Z","timestamp":1417046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2015,6]]},"abstract":"Abstract<\/jats:title>\n \n Introduction<\/jats:title>\n Vitiligo is a common progressive depigmentation of the skin due to selective destruction of melanocytes. Nowadays increasing evidences support the hypothesis of an autoimmune etiology.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n In order to sustain the role of T\u2010helper\u201017 lymphocytes in the pathogenesis of vitiligo, we\u00a0measured the serum levels of interleukin (\n IL<\/jats:styled-content>\n )\u201023 (an important regulator of this subset) using a quantitative enzyme immunoassay technique in 12 males and 16 females (ages ranging from 18 to 58\u00a0years) affected by non\u2010segmental vitiligo and compared the results with a group of healthy donors.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n IL<\/jats:styled-content>\n \u201023 serum levels were significantly higher in patients with\u00a0vitiligo as compared with controls. There was a significant positive correlation of\n IL<\/jats:styled-content>\n \u201023 serum levels with disease duration and extent of vitiligo and disease activity.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n The inhibition of\n IL<\/jats:styled-content>\n \u201023 might be a novel strategy in the therapy of autoimmune inflammatory diseases like\u00a0vitiligo.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ijd.12392","type":"journal-article","created":{"date-parts":[[2014,11,27]],"date-time":"2014-11-27T01:57:26Z","timestamp":1417053446000},"page":"672-674","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Increased serum levels of interleukin\u201023 circulating in patients with non\u2010segmental generalized vitiligo"],"prefix":"10.1111","volume":"54","author":[{"given":"Mario","family":"Vaccaro","sequence":"first","affiliation":[{"name":"Institute of Dermatology University of Messina Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serafinella P.","family":"Cannav\u00f2","sequence":"additional","affiliation":[{"name":"Institute of Dermatology University of Messina Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selene","family":"Imbesi","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine School and Division of Allergy and Clinical Immunology University of Messina Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariateresa","family":"Cristani","sequence":"additional","affiliation":[{"name":"Department Farmaco\u2010Biologico School of Pharmacy University of Messina Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Barbuzza","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine School and Division of Allergy and Clinical Immunology University of Messina Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Tigano","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine School and Division of Allergy and Clinical Immunology University of Messina Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastiano","family":"Gangemi","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine School and Division of Allergy and Clinical Immunology University of Messina Messina Italy"},{"name":"Institute of Biomedicine and Molecular Immunology \u201cA. Monroy\u201d (IBIM) Consiglio Nazionale delle Ricerche (CNR) Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,11,27]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.5.3055"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.1993.tb00023.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2011.02.004"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2001.04288.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/15569527.2011.560913"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2010.00688.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6101(03)00002-9"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201242598"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/07853890.2011.577093"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2010.03972.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08785.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2012.03.044"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2007.02228.x"},{"key":"e_1_2_5_15_1","first-page":"849","article-title":"Keratinocyte dysfunction in vitiligo epidermis: cytokine microenvironment and correlation to keratinocyte apoptosis","volume":"24","author":"Moretti S","year":"2009","journal-title":"Histol Histopathol"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.09.048"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-010-1040-9"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2011.03522.x"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fijd.12392","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.12392","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T22:57:07Z","timestamp":1696287427000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.12392"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,27]]},"references-count":17,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["10.1111\/ijd.12392"],"URL":"https:\/\/doi.org\/10.1111\/ijd.12392","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,27]]},"assertion":[{"value":"2012-10-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-06-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-11-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}