{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T01:50:01Z","timestamp":1773280201943,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,2,14]],"date-time":"2014-02-14T00:00:00Z","timestamp":1392336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Psoriasis is a chronic inflammatory process associated with an increased risk of cardiovascular risk factors. s<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>40<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content> has been suggested to have a possible role in the pathogenesis, of psoriasis and is known to be associated with inflammation, atherogenesis and cardiovascular events. This study investigated cardiovascular risk factors (s<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>40<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content> and homocysteine) as well as subclinical atherosclerosis indicators in psoriatic patients and control subjects. The study included 56 consecutive patients with chronic plaque\u2010type psoriasis and 53 age and gender matched healthy controls admitted to a university hospital. Serum s<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>40<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content> and homocysteine levels were measured by <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>. Carotid artery intima\u2010media thickness and brachial artery flow mediated dilatation (<jats:styled-content style=\"fixed-case\">FMD<\/jats:styled-content>) measurements were determined ultrasonographically. Subjects who had a history of cardiovascular diseases and cardiovascular risk factors and receiving any systemic treatment were excluded from the study. Plasma s<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>40<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content> levels were significantly higher in psoriasis patients compared with healthy controls (1.33\u00a0\u00b1\u00a00.72 vs. 0.98\u00a0\u00b1\u00a00.70\u00a0ng\/ml <jats:italic>P<\/jats:italic>\u00a0=\u00a00.012), whereas plasma homocysteine levels did not differ significantly between the two groups. <jats:styled-content style=\"fixed-case\">FMD<\/jats:styled-content> was significantly reduced in the psoriasis group compared to the controls (3.83\u00a0\u00b1\u00a05.03 vs. 8.45\u00a0\u00b1\u00a07.27% <jats:italic>P\u00a0<\/jats:italic>=\u00a00.0001). Multiple linear regression analyses indicated a significant association between psoriasis, s<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>40<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">FMD<\/jats:styled-content>. Psoriatic patients had higher s<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>40<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content> levels than healthy controls, which may lead to an increase in cardiovascular diseases. s<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>40<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content> may be a more reliable and early predictive marker of cardiovascular events in psoriatic patients. New treatment options that will be developed over s<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>40<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content> will benefit in prevention of psoriasis and its cardiovascular comorbidities.<\/jats:p>","DOI":"10.1111\/ijd.12397","type":"journal-article","created":{"date-parts":[[2014,2,17]],"date-time":"2014-02-17T04:02:27Z","timestamp":1392609747000},"page":"503-509","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Evaluation of serum s<scp>CD<\/scp>40<scp>L<\/scp> and homocysteine levels with subclinical atherosclerosis indicators in patients with psoriasis: a pilot study"],"prefix":"10.1111","volume":"53","author":[{"given":"\u0130jlal","family":"Erturan","sequence":"first","affiliation":[{"name":"Department of Dermatology Faculty of Medicine S\u00fcleyman Demirel University Isparta Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Banu Kale","family":"K\u00f6ro\u011flu","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Department of Internal Medicine Faculty of Medicine S\u00fcleyman Demirel University Isparta Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Adilo\u011flu","sequence":"additional","affiliation":[{"name":"Department of Microbiology Ankara Training and Research Hospital Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali M.","family":"Ceyhan","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine S\u00fcleyman Demirel University Isparta Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vahide B.","family":"Akkaya","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine S\u00fcleyman Demirel University Isparta Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Numan","family":"Tamer","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Department of Internal Medicine Faculty of Medicine S\u00fcleyman Demirel University Isparta Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u0131nar Y.","family":"Ba\u015fak","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine S\u00fcleyman Demirel University Isparta Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selma","family":"Korkmaz","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine S\u00fcleyman Demirel University Isparta Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0130smail H.","family":"Ersoy","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Department of Internal Medicine Faculty of Medicine S\u00fcleyman Demirel University Isparta Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osman","family":"K\u0131l\u0131n\u00e7","sequence":"additional","affiliation":[{"name":"Department of Microbiology Faculty of Medicine S\u00fcleyman Demirel University Isparta Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,2,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2010.0930"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2008.02936.x"},{"key":"e_1_2_6_4_1","first-page":"1073","article-title":"Dermacase. 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