{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T02:54:04Z","timestamp":1784170444768,"version":"3.55.0"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,12,30]],"date-time":"2013-12-30T00:00:00Z","timestamp":1388361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The relationship between the occurrence of skin diseases and skin tattoos remains unclear. Dermatologic disorders have been reported to occur in about 2% of cases. In addition, tattoo pigment can migrate to the regional lymph nodes through the lymphatic vessels and subsequently mimic metastatic disease from melanoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A 23\u2010year\u2010old Caucasian man presented with a pigmented lesion on the left scapular region, which had slowly enlarged over time. The patient exhibited an extensive tattoo on the left upper arm, left shoulder, and part of the upper back. His medical history was unremarkable. The pigmented lesion was excised. Histology confirmed malignant melanoma. Ultrasound examination of the abdomen, neck, and inguinal and axillary lymph nodes and a total body computed tomography scan showed no sign of disease. A re\u2010excision with 2\u2010cm margins and sentinel lymph node biopsy (<jats:styled-content style=\"fixed-case\">SLNB<\/jats:styled-content>) were performed. Two grossly enlarged, black sentinel lymph nodes (<jats:styled-content style=\"fixed-case\">SLN<\/jats:styled-content>s) highly suggestive of melanoma metastases were removed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No evidence of melanoma metastasis was found in any of the sampled tissues. Large amounts of pigment were present within the subcapsular space and sinusoid areas of the two clinically suspicious lymph nodes. Immunohistochemical analysis was negative.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Sentinel lymph node biopsy is widely performed in cutaneous melanoma. Histologic confirmation of any enlarged, pigmented <jats:styled-content style=\"fixed-case\">SLN<\/jats:styled-content> is essential prior to radical surgery, especially when pigmented <jats:styled-content style=\"fixed-case\">SLN<\/jats:styled-content>s are found near a tattoo. Tattoo pigments may deposit in the regional lymph nodes and may clinically mimic metastatic disease. A history of tattooing should be considered in all melanoma patients eligible for <jats:styled-content style=\"fixed-case\">SLNB<\/jats:styled-content>. In a finding of darkly pigmented nodes during <jats:styled-content style=\"fixed-case\">SLNB<\/jats:styled-content>, radical lymphadenectomy should be withheld until immunohistologic confirmation of metastasis in the <jats:styled-content style=\"fixed-case\">SLN<\/jats:styled-content> is obtained.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.12417","type":"journal-article","created":{"date-parts":[[2013,12,30]],"date-time":"2013-12-30T09:57:15Z","timestamp":1388397435000},"page":"773-776","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Pigmentation of axillary sentinel nodes from extensive skin tattoo mimics metastatic melanoma: case report"],"prefix":"10.1111","volume":"53","author":[{"given":"Ausilia Maria","family":"Manganoni","sequence":"first","affiliation":[{"name":"Department of Dermatology Brescia Civic Hospital Brescia 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