{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:10:36Z","timestamp":1787062236724,"version":"build-2736575974"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,3,6]],"date-time":"2014-03-06T00:00:00Z","timestamp":1394064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2015,2]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Pemphigus vulgaris (\n PV<\/jats:styled-content>\n ) is a rare autoimmune disease that involves the skin and mucosa. The etiology of\n PV<\/jats:styled-content>\n is multifactorial and includes genetic, environmental, hormonal, and immunological factors.\n <\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n \n The purpose of this study was to examine the relationships between human leukocyte antigen (\n HLA<\/jats:styled-content>\n ) class II alleles associated with\n PV<\/jats:styled-content>\n and variations in the disease phenotype.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Forty\u2010four\n PV<\/jats:styled-content>\n patients were diagnosed and analyzed at the Bullous Disorders Unit in cooperation with the Institute of Immunology, Faculty of Medicine, Comenius University, Bratislava, Slovakia.\n HLA<\/jats:styled-content>\n class II alleles previously found to be associated with\n PV<\/jats:styled-content>\n (\n DRB<\/jats:styled-content>\n 1*04:02,\n DRB<\/jats:styled-content>\n 1*04:04,\n DRB<\/jats:styled-content>\n 1*14:54,\n DRB<\/jats:styled-content>\n 1*14:04,\n DRB<\/jats:styled-content>\n 1*14:05,\n DQB<\/jats:styled-content>\n 1*03:02 and\n DQB<\/jats:styled-content>\n 1*05:03) were analyzed according to disease severity,\n PV<\/jats:styled-content>\n type, and gender distribution.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Correlations emerged between\n PV<\/jats:styled-content>\n severity scores and\n HLA<\/jats:styled-content>\n alleles. The\n DRB<\/jats:styled-content>\n 1*04:02 and\n DQB<\/jats:styled-content>\n 1*03:02 alleles were associated with severe\n PV<\/jats:styled-content>\n (\n P\u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 0.001);\n DRB<\/jats:styled-content>\n 1*04:02 was associated with the mucocutaneous type (\n P<\/jats:italic>\n \u00a0=\n \u00a0<\/jats:italic>\n 0.024), and\n DQB<\/jats:styled-content>\n 1*03:02 was found more frequently in female than in male patients (\n P<\/jats:italic>\n \u00a0=\n \u00a0<\/jats:italic>\n 0.016). Analyses of the other alleles did not reveal significant associations with the clinical parameters evaluated.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n The HLA DRB1* and\n DQB<\/jats:styled-content>\n 1* alleles influence susceptibility to\n PV<\/jats:styled-content>\n and may contribute to\n PV<\/jats:styled-content>\n severity and type. These results suggest that genetic background may contribute to disease outcome by affecting the disease course and efficacy of treatment because some of the alleles were found significantly more frequently in patients with severe disease.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ijd.12418","type":"journal-article","created":{"date-parts":[[2014,3,6]],"date-time":"2014-03-06T23:24:02Z","timestamp":1394148242000},"page":"168-173","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["HLA DRB<\/scp>\n 1* and\n DQB<\/scp>\n 1* alleles are associated with disease severity in patients with pemphigus vulgaris"],"prefix":"10.1111","volume":"54","author":[{"given":"Danka","family":"Svecova","sequence":"first","affiliation":[{"name":"Department of Dermatovenereology Faculty of Medicine Comenius University Bratislava Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuzana","family":"Parnicka","sequence":"additional","affiliation":[{"name":"Institute of Immunology Faculty of Medicine Comenius University Bratislava Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Pastyrikova","sequence":"additional","affiliation":[{"name":"Department of Dermatovenereology Faculty of Medicine Comenius University Bratislava Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Slavomir","family":"Urbancek","sequence":"additional","affiliation":[{"name":"Department of Dermatovenereology Faculty of Medicine Slovak Medical University F. D. Roosvelt Hospital Banska Bystrica Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Luha","sequence":"additional","affiliation":[{"name":"Institute of Medical Biology, Genetics and Clinical Genetics Faculty of Medicine Comenius University Bratislava Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milan","family":"Buc","sequence":"additional","affiliation":[{"name":"Institute of Immunology Faculty of Medicine Comenius University Bratislava Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,3,6]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"\u0160vecov\u00e1D.Pemphigus Bratislava: Bonus2009:23\u201346."},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2009.10.009"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60826-4"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03659.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(97)70324-4"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2005.09.003"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.11040.x"},{"key":"e_1_2_7_9_1","first-page":"471","article-title":"High susceptibility to pemphigus vulgaris due to HLA\u2010DRB1*14:54 in the Slovak population","volume":"40","author":"P\u00e1rnick\u00e1 Z","year":"2013","journal-title":"Int J Dermatol"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2011.03.015"},{"key":"e_1_2_7_11_1","unstructured":"WerthVP.Measuring extent and activity of disease in pemphigus. 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