{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:52:27Z","timestamp":1787014347312,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,4,2]],"date-time":"2014-04-02T00:00:00Z","timestamp":1396396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2015,1]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Stevens\u2013Johnson syndrome (\n SJS<\/jats:styled-content>\n ) and toxic epidermal necrolysis (\n TEN<\/jats:styled-content>\n ) are severe disorders with significant morbidity and mortality. The therapeutic use of intravenous immunoglobulin (IVIG) is based on limited data.\n <\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n \n This systematic review evaluates the existing literature to determine if IVIG impacts the standardized mortality rate (\n SMR<\/jats:styled-content>\n ) in patients with\n SJS<\/jats:styled-content>\n or\n TEN<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n The\n MEDLINE<\/jats:styled-content>\n database was searched for the period 1966\u20132011 for pertinent studies. The bibliographies of selected references were also reviewed for additional studies. Inclusion criteria required the studies to refer to patients who received IVIG for\n SJS<\/jats:styled-content>\n or\n TEN<\/jats:styled-content>\n , the severity of which was determined using the\n SCORTEN<\/jats:styled-content>\n system. Thirteen studies were used in the final analysis. Demographic data, IVIG dosing,\n SCORTEN<\/jats:styled-content>\n score, and mortality rates were extracted.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of the 13 studies, eight included a control group. Meta\u2010analysis revealed that differences in\n SMR<\/jats:styled-content>\n s were not significant (\u22120.322, 95% confidence interval [\n CI<\/jats:styled-content>\n ] \u22120.766 to 0.122;\n P\u00a0<\/jats:italic>\n =\u00a00.155). The overall\n SMR<\/jats:styled-content>\n point estimate for all 13 studies was 0.814 (95%\n CI<\/jats:styled-content>\n 0.617\u20131.076). Meta\u2010regression demonstrated a strong inverse correlation between IVIG dosage and\n SMR<\/jats:styled-content>\n s (slope: \u22120.59, 95%\n CI<\/jats:styled-content>\n \u22120.14 to \u22121.03;\n P\u00a0<\/jats:italic>\n =\u00a00.009).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Intravenous\n IG<\/jats:styled-content>\n at dosages of \u22652\u00a0g\/kg appears to significantly decrease mortality in patients with\n SJS<\/jats:styled-content>\n or\n TEN<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ijd.12423","type":"journal-article","created":{"date-parts":[[2014,4,2]],"date-time":"2014-04-02T22:17:54Z","timestamp":1396477074000},"page":"108-115","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":86,"title":["Intravenous immunoglobulin in the treatment of\n S<\/scp>\n tevens\u2013\n J<\/scp>\n ohnson syndrome and toxic epidermal necrolysis: a meta\u2010analysis with meta\u2010regression of observational studies"],"prefix":"10.1111","volume":"54","author":[{"given":"Stacy J.","family":"Barron","sequence":"first","affiliation":[{"name":"Department of Pediatrics University of California Los Angeles Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael T.","family":"Del Vecchio","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Temple University School of Medicine Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen C.","family":"Aronoff","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Temple University School of Medicine Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,4,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2008.06.004"},{"key":"e_1_2_6_3_1","first-page":"7","article-title":"IVIG for the treatment of toxic epidermal necrolysis","volume":"12","author":"Mittmann N","year":"2007","journal-title":"Skin Therapy Lett"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1586\/17469872.2.3.299"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1993.01680220104023"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-032303004-5.50165-4"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.282.5388.490"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/2042098611404094"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.10965.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.15.2008"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.BCR.0000216532.71360.9B"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2000.00061.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/jech.38.1.85"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a114083"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.2307\/3001666"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186"},{"key":"e_1_2_6_17_1","first-page":"719","article-title":"Statistical aspects of the analysis of data from retrospective studies of disease","volume":"22","author":"Mantel N","year":"1959","journal-title":"J Natl Cancer Inst"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7109.629"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2004.12.007"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6701653"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.08.039"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2006.02082.x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.BCR.0000124746.33279.86"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.06.085"},{"key":"e_1_2_6_25_1","first-page":"2494","article-title":"Intravenous immunoglobulin therapy for children with Stevens\u2013Johnson syndrome","volume":"27","author":"Morici M","year":"2000","journal-title":"J Rheumatol"},{"key":"e_1_2_6_26_1","first-page":"430","article-title":"High\u2010dose intravenous immunoglobulin for severe drug reactions: efficacy in toxic epidermal necrolysis","volume":"83","author":"Campione E","year":"2003","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_6_27_1","first-page":"743","article-title":"High\u2010dose intravenous immunoglobulins in the treatment of Stevens\u2013Johnson syndrome and toxic epidermal necrolysis in Chinese patients: a retrospective study of 82 cases","volume":"20","author":"Chen J","year":"2010","journal-title":"Eur J Dermatol"},{"key":"e_1_2_6_28_1","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1080\/00015550510038232","article-title":"Toxic epidermal necrolysis: analysis of clinical course and SCORTEN\u2010based comparison of mortality rate and treatment modalities in Korean patients","volume":"85","author":"Kim KJ","year":"2005","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2010.03826.x"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00105-006-1104-0"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2006.08.014"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1169"},{"key":"e_1_2_6_33_1","first-page":"29","article-title":"Stevens\u2013Johnson syndrome and toxic epidermal necrolysis: efficacy of intravenous immunoglobulin and a review of treatment options","volume":"50","author":"Teo L","year":"2009","journal-title":"Singapore Med J"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.139.1.39"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2009.04166.x"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2005.01863.x"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.BCR.0000105096.93526.27"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.139.1.33"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fijd.12423","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fijd.12423","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.12423","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T16:51:35Z","timestamp":1696351895000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.12423"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,2]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.1111\/ijd.12423"],"URL":"https:\/\/doi.org\/10.1111\/ijd.12423","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718338668.793517984","asserted-by":"object"}]},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,2]]},"assertion":[{"value":"2014-04-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}