{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T21:42:21Z","timestamp":1770327741968,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,6,25]],"date-time":"2014-06-25T00:00:00Z","timestamp":1403654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Post\u2010adolescent acne has been defined as acne in a patient aged &gt;25\u00a0years. Acne vulgaris first develops at the onset of puberty as a result of hormonal changes. During puberty, there is a transient decline in insulin sensitivity. We hypothesized that insulin resistance might persist after puberty in patients with post\u2010adolescent acne.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study was conducted in order to investigate the relationship between post\u2010adolescent acne and insulin resistance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study population comprised 35 patients with post\u2010adolescent acne and 35 healthy control subjects. The parameters measured were fasting blood glucose, insulin, aspartate aminotransferase (<jats:styled-content style=\"fixed-case\">AST<\/jats:styled-content>) and alanine aminotransferase (<jats:styled-content style=\"fixed-case\">ALT<\/jats:styled-content>), total cholesterol (<jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>), triglycerides, high\u2010density lipoprotein cholesterol (<jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>), and low\u2010density lipoprotein cholesterol (<jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>). The homeostasis model assessment of insulin resistance (<jats:styled-content style=\"fixed-case\">HOMA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content>) index was calculated for each individual.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No significant differences were observed between patients with post\u2010adolescent acne and control subjects in fasting blood glucose, fasting insulin, <jats:styled-content style=\"fixed-case\">AST<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> ALT<\/jats:styled-content>, triglyceride and <jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content>\u2010C levels, and <jats:styled-content style=\"fixed-case\">HOMA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content> index. There were also no correlations between these parameters and the severity of acne.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study suggests that insulin resistance may not play a major role in the pathogenesis of post\u2010adolescent acne. Hormonal changes, genetic susceptibility, stress, the use of cosmetics, drugs, and environmental factors should be considered in the development of post\u2010adolescent acne.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.12426","type":"journal-article","created":{"date-parts":[[2014,6,25]],"date-time":"2014-06-25T06:49:00Z","timestamp":1403678940000},"page":"662-666","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Insulin resistance in patients with post\u2010adolescent acne"],"prefix":"10.1111","volume":"54","author":[{"given":"Ilknur","family":"Balta","sequence":"first","affiliation":[{"name":"Department of Dermatology Kecioren Training and Research Hospital Ministry of Health Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ozlem","family":"Ekiz","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tayfur Ata Sokmen School of Medicine Mustafa Kemal University 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