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The aim of this study was to compare the efficacy and safety of topical ivermectin vs. crotamiton cream 10% for the treatment of scabies. In total, 340 patients with scabies were enrolled, and randomized into two groups. The first group received 1% ivermectin applied topically to the affected skin. The dose employed was 400\u00a0<jats:italic>\u03bc<\/jats:italic>g\/kg, repeated once the following week, and the second group received crotamiton 10% cream and were told to apply this twice daily for five consecutive days. Treatment was evaluated at intervals of two and four\u00a0weeks, and if there was treatment failure at the 2\u2010week follow\u2010up, treatment was repeated. Two applications of topical ivermectin provided a cure rate of 64.7% at the 2\u2010week follow\u2010up, which increased to 82.3% at the 4\u2010week follow\u2010up after repeating the treatment. Treatment with single applications of crotamiton cream 10% was effective in 41.2% of patients at the 2\u2010week follow\u2010up, which increased to 64.7% at the 4\u2010week follow\u2010up after this treatment was repeated. Ivermectin was quite safe in our cases. Two applications of ivermectin were as effective as single applications of crotamiton 10% cream at the 2\u2010week follow\u2010up. After repeating the treatment, ivermectin was superior to crotamiton cream 10% at the 4\u2010week follow\u2010up.<\/jats:p>","DOI":"10.1111\/ijd.12447","type":"journal-article","created":{"date-parts":[[2014,6,5]],"date-time":"2014-06-05T08:36:47Z","timestamp":1401957407000},"page":"904-908","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Topical ivermectin versus crotamiton cream 10% for the treatment of scabies"],"prefix":"10.1111","volume":"53","author":[{"given":"Mohamad","family":"Goldust","sequence":"first","affiliation":[{"name":"Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elham","family":"Rezaee","sequence":"additional","affiliation":[{"name":"Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramin","family":"Raghiafar","sequence":"additional","affiliation":[{"name":"Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,6,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.7748\/ns2010.11.25.9.42.c8076"},{"key":"e_1_2_7_3_1","first-page":"1005","article-title":"Permethrin for scabies in children","volume":"56","author":"Albakri L","year":"2010","journal-title":"Can Fam Physician"},{"key":"e_1_2_7_4_1","first-page":"37","article-title":"Ivermectin vs. lindane in the treatment of scabies","volume":"59","author":"Goldust M","year":"2013","journal-title":"Ann Parasitol"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.c4456"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1553-2712.2010.00811.x"},{"key":"e_1_2_7_7_1","first-page":"31","article-title":"Comparison of permethrin 2.5% cream vs. Tenutex emulsion for the treatment of scabies","volume":"59","author":"Goldust M","year":"2013","journal-title":"Ann Parasitol"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/0971-4065.65302"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medmal.2010.07.011"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.12079"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2010.03.008"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000756"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546634.2013.782093"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546634.2012.755251"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546631003649687"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/15569527.2013.768258"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546634.2012.723122"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00195-10"},{"key":"e_1_2_7_19_1","first-page":"251","article-title":"Treatment of scabies: comparison of ivermectin vs. lindane lotion 1%","volume":"20","author":"Mohebbipour A","year":"2012","journal-title":"Acta Dermatovenerol Croat"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2011.01481.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.62748"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/1746-6148-6-29"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMct0910329"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/15569520600860520"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1992.tb03958.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.100571"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2011.01680.x"},{"key":"e_1_2_7_28_1","first-page":"CD000320","article-title":"Interventions for treating scabies","author":"Strong M","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.2174\/138920112800399248"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.84063"},{"key":"e_1_2_7_31_1","first-page":"174","article-title":"[Erythrodermic crusted scabies induced by corticosteroids treated with ivermectin. 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