{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T15:07:38Z","timestamp":1748358458260},"reference-count":28,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,7,11]],"date-time":"2014-07-11T00:00:00Z","timestamp":1405036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Bullous pemphigoid (<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>) is the most frequently encountered autoimmune blistering disorder, affecting mainly elderly population. The aim of the study was to assess the incidence of <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> in Podlaskie Province (north\u2010east Poland) in 1999\u20132012, socio\u2010demographic characteristics and mortality of patients with <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The number of newly diagnosed (in two regional hospitals) cases of <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> per million inhabitants of the province in consecutive years was calculated and analysis of age, sex, and residency of patients performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 122 cases of <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> were diagnosed (in 52 males and 70 females). The average annual incidence was 7.38\u00a0\u00b1\u00a03.51 per million inhabitants: 5.70\u00a0\u00b1\u00a04.16 and 9.26\u00a0\u00b1\u00a04.40 in urban and rural areas, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05, respectively, and had an increasing trend over the period analyzed. Age of patients with <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> was 74.18\u00a0\u00b1\u00a012.12. The incidence among men and women over 75\u00a0years of age was 86.67\u00a0\u00b1\u00a061.39 and 51.49\u00a0\u00b1\u00a041.44, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05, respectively. The 1\u2010year mortality of patients was 32.35 and 18.42% (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) in men and women, respectively. Overall mortality was 36.11%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The incidence of <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> in Podlaskie Province is almost twice as high among residents of rural than urban areas, and in males than females in advanced age. The results suggest that the incidence of <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> will be increasing in an aging society, as will its impact on the quality of life of the population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.12492","type":"journal-article","created":{"date-parts":[[2014,7,11]],"date-time":"2014-07-11T08:18:32Z","timestamp":1405066712000},"update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Incidence and mortality of bullous pemphigoid in north\u2010east Poland (Podlaskie Province), 1999\u20132012: a retrospective bicentric cohort study"],"prefix":"10.1111","volume":"53","author":[{"given":"Agnieszka B.","family":"Serwin","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology Medical University of Bialystok Bialystok Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewa","family":"Musialkowska","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Medical University of Bialystok Bialystok Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Piascik","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Medical University of Bialystok Bialystok Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,7,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61140-4"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0738-081X(98)00008-X"},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"313","DOI":"10.2340\/000155555313315","article-title":"The effects of X\u2010ray, ultraviolet and infrared irradiation on the basement membrane zone antibody reaction of the human skin in vitro","volume":"55","author":"Remy W","year":"1975","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-0844(199806)16:2<107::AID-CBF774>3.0.CO;2-3"},{"key":"e_1_2_7_6_1","first-page":"360","article-title":"Epidemiological and clinical analysis of pemphigoid patients in northeastern Poland in 2000\u20132005","volume":"13","author":"Serwin AB","year":"2007","journal-title":"Med Sci Monit"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0926-9959.2001.00275.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09300.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2008.06976_supp.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06662.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.35"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.a180"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1995.01690130050009"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(99)70061-7"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12065"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10413.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000345625"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.138.7.903"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011592"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2005.23628.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.134.9.1075"},{"key":"e_1_2_7_22_1","unstructured":"Chief Statistical Office.Statistical yearbook of the Republic of Poland. 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