{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:35:06Z","timestamp":1791318906142,"version":"4.3.1"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,3,13]],"date-time":"2015-03-13T00:00:00Z","timestamp":1426204800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Melanoma is considered a heterogeneous tumor with genetic and environmental factors involved in its pathogenesis. The impact of these factors varies depending on age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to characterize the epidemiological, phenotypic, and histological features of patients with melanoma according to three age groups: \u226440, 41\u201365, and &gt;65\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 1122 consecutive patients with invasive melanoma definitively treated in our institution since January 2000 were selected from our melanoma database. Epidemiological, phenotypic, and histological data were retrieved and analyzed as a function of age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Female patients predominated in the younger age group. The location of cutaneous malignant melanoma differed with age. In the younger and middle age groups, tumors presented mainly on the trunk, while in the older group they were mainly found on the head\/neck. Signs of actinic damage such as actinic keratoses, solar lentigines, or other skin tumors increased with age, while genetic factors such as family history of melanoma or a high number of common melanocytic nevi were more frequent in the younger group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results suggest that melanoma development in younger patients is the result of genetic factors, particularly related to multiple nevi, whereas in older patients environmental factors such as severe chronic sun exposure play a major role.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.12496","type":"journal-article","created":{"date-parts":[[2015,3,14]],"date-time":"2015-03-14T00:38:50Z","timestamp":1426293530000},"page":"778-784","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Age\u2010related characteristics of cutaneous melanoma in a <scp>S<\/scp>panish <scp>M<\/scp>editerranean population"],"prefix":"10.1111","volume":"54","author":[{"given":"Iria","family":"Montero","sequence":"first","affiliation":[{"name":"Department of Dermatology Instituto Valenciano de Oncolog\u00eda Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celia","family":"Requena","sequence":"additional","affiliation":[{"name":"Department of Dermatology Instituto Valenciano de Oncolog\u00eda Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Traves","sequence":"additional","affiliation":[{"name":"Department of Pathology Instituto Valenciano de Oncolog\u00eda Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaida","family":"Garc\u00eda\u2010Casado","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology Instituto Valenciano de Oncolog\u00eda Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajiv","family":"Kumar","sequence":"additional","affiliation":[{"name":"Division of Molecular Genetic Epidemiology German Cancer Research Center Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Nagore","sequence":"additional","affiliation":[{"name":"Department of Dermatology Instituto Valenciano de Oncolog\u00eda Valencia Spain"},{"name":"Universidad Cat\u00f3lica de Valencia Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,13]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(99)00283-X"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2004.06.003"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.05708.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwp307"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2008.04.006"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2007.03408.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2005.03.034"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1996.302"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2011.00880.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2010.03960.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-004-4325-5"},{"key":"e_1_2_5_13_1","doi-asserted-by":"crossref","first-page":"50","DOI":"10.2340\/00015555-0004","article-title":"Clinicopathological analysis of 1571 cutaneous malignant melanomas in Valencia, Spain: factors related to tumour thickness","volume":"86","author":"Nagore E","year":"2006","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_5_14_1","first-page":"559","article-title":"Skin diseases with high public health impact. 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