{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T13:06:00Z","timestamp":1789909560801,"version":"4.0.1"},"reference-count":20,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,7,11]],"date-time":"2014-07-11T00:00:00Z","timestamp":1405036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2014,9]]},"abstract":"Abstract<\/jats:title>Anogenital warts are caused by human papillomavirus (HPV<\/jats:styled-content>), over 30 types of which are infectious for the anogenital tract. Without treatment, warts may regress spontaneously, remain unchanged, or increase in number and size. This study compared the efficacy of a topical 5% potassium hydroxide (KOH<\/jats:styled-content>) solution with that of a topical 0.5% 5\u2010fluorouracil (5\u2010FU<\/jats:styled-content>) and 10% salicylic acid (SA<\/jats:styled-content>) combination in the treatment of anogenital warts. Sixty patients were randomly assigned to receive topical KOH<\/jats:styled-content> or 5\u2010FU<\/jats:styled-content>\u00a0+\u00a0SA<\/jats:styled-content>. Both groups demonstrated a significant decrease in numbers of lesions (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.05), but this difference was not significant at week 12 (P\u00a0<\/jats:italic>>\u00a00.05). The mean number of lesions decreased from baseline to week 12 from 17.03\u00a0\u00b1\u00a012.64 to 3.73\u00a0\u00b1\u00a07.30 and from 16.13\u00a0\u00b1\u00a012.97 to 3.10\u00a0\u00b1\u00a04.90 in the KOH<\/jats:styled-content> and 5\u2010FU<\/jats:styled-content>\u00a0+\u00a0SA<\/jats:styled-content> groups, respectively (P\u00a0<\/jats:italic><\u00a00.001). Excellent clearance was achieved by 70.0 and 76.7% of patients in the KOH<\/jats:styled-content> and 5\u2010FU<\/jats:styled-content>\u00a0+\u00a0SA<\/jats:styled-content> groups, respectively. Marked improvement was seen in 13.3 and 20.0% of patients in the KOH<\/jats:styled-content> and 5\u2010FU<\/jats:styled-content>\u00a0+\u00a0SA<\/jats:styled-content> groups, respectively. At week 16, relapse was observed in two patients in the KOH<\/jats:styled-content> group and three in the 5\u2010FU<\/jats:styled-content>\u00a0+\u00a0SA<\/jats:styled-content> group (P\u00a0<\/jats:italic>>\u00a00.05). No serious adverse events were reported. Neither treatment was more efficacious. Safety and ease of application are important goals in treatments for anogenital warts. A 5% KOH<\/jats:styled-content> solution is a promising alternative treatment because it is effective and inexpensive and causes minimal side effects.<\/jats:p>","DOI":"10.1111\/ijd.12505","type":"journal-article","created":{"date-parts":[[2014,7,11]],"date-time":"2014-07-11T08:18:37Z","timestamp":1405066717000},"page":"1145-1150","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["A comparison of a 5% potassium hydroxide solution with a 5\u2010fluorouracil and salicylic acid combination in the treatment of patients with anogenital warts: a randomized, open\u2010label clinical trial"],"prefix":"10.1111","volume":"53","author":[{"given":"Selda","family":"I\u015fik","sequence":"first","affiliation":[{"name":"Department of Dermatology Faculty of Medicine \u00c7anakkale Onsekiz Mart University \u00c7anakkale Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafet","family":"Koca","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine B\u00fclent Ecevit University Zonguldak Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fclben","family":"Sarici","sequence":"additional","affiliation":[{"name":"Department of Dermatology State Hospital Eski\u015fehir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilmi Cevdet","family":"Altinyazar","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine Sel\u00e7uk University Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,7,11]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1363\/3600604"},{"key":"e_1_2_5_3_1","first-page":"5","article-title":"An evidence\u2010based review of medical and surgical 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