{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T13:17:37Z","timestamp":1773148657854,"version":"3.50.1"},"reference-count":10,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,6,5]],"date-time":"2014-06-05T00:00:00Z","timestamp":1401926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Deficiency of interleukin\u201036 (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201036) receptor antagonist (<jats:styled-content style=\"fixed-case\">DITRA<\/jats:styled-content>;<jats:styled-content style=\"fixed-case\"> OMIM<\/jats:styled-content> 614204) is a rare autoinflammatory disorder characterized by periodic fever associated with a generalized erythematous and pustular skin rash. <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> 6\u2010year\u2010old Arab\u2010Palestinian boy presented with a history of periodic fever and unremitting, erythematous, scaly skin rash accompanied by widespread pustules that had been present since the age of one\u00a0month. The patient's skin lesions were compatible with generalized pustular psoriasis. Sequence analysis revealed a homozygous nonsense mutation, c.28C&gt;T (p.Arg10X) in the <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>36<jats:styled-content style=\"fixed-case\">RN<\/jats:styled-content><\/jats:italic> gene. The patient improved with oral methotrexate in combination with oral and topical corticosteroids. The molecular basis for <jats:styled-content style=\"fixed-case\">DITRA<\/jats:styled-content> has only recently been identified, and the mutation spectrum for this disorder in many populations is still obscure. This paper reports the presence of the c.28C&gt;T mutation in an Arab\u2010Palestinian patient and thus represents the first description of this mutation in a non\u2010Japanese subject.<\/jats:p>","DOI":"10.1111\/ijd.12525","type":"journal-article","created":{"date-parts":[[2014,6,5]],"date-time":"2014-06-05T08:37:34Z","timestamp":1401957454000},"page":"866-868","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["<i><scp>IL<\/scp>36<scp>RN<\/scp><\/i> mutation causing generalized pustular psoriasis in a Palestinian patient"],"prefix":"10.1111","volume":"53","author":[{"given":"Yael","family":"Renert\u2010Yuval","sequence":"first","affiliation":[{"name":"Department of Dermatology Hadassah\u2010Hebrew University Medical Center Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liran","family":"Horev","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hadassah\u2010Hebrew University Medical Center Jerusalem Israel"},{"name":"Center for Genetic Diseases of the Skin and Hair Hadassah\u2010Hebrew University Medical Center Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofia","family":"Babay","sequence":"additional","affiliation":[{"name":"Center for Genetic Diseases of the Skin and Hair Hadassah\u2010Hebrew University Medical Center Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Spiro","family":"Tams","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Palestinian Al Quds University Abu Dis, Palestinian Authority"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuval","family":"Ramot","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hadassah\u2010Hebrew University Medical Center Jerusalem Israel"},{"name":"Center for Genetic Diseases of the Skin and Hair Hadassah\u2010Hebrew University Medical Center Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abraham","family":"Zlotogorski","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hadassah\u2010Hebrew University Medical Center Jerusalem Israel"},{"name":"Center for Genetic Diseases of the Skin and Hair Hadassah\u2010Hebrew University Medical Center Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vered","family":"Molho\u2010Pessach","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hadassah\u2010Hebrew University Medical Center Jerusalem Israel"},{"name":"Center for Genetic Diseases of the Skin and Hair Hadassah\u2010Hebrew University Medical Center Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,6,5]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1013068"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2013.03.016"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2011.3014"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.490"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2011.07.022"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000346572"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.44"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12227"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.10953.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.22203"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fijd.12525","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.12525","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T03:10:10Z","timestamp":1696302610000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.12525"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,5]]},"references-count":10,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["10.1111\/ijd.12525"],"URL":"https:\/\/doi.org\/10.1111\/ijd.12525","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,5]]},"assertion":[{"value":"2014-06-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}