{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T04:02:50Z","timestamp":1746331370798,"version":"3.40.4"},"reference-count":41,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,6,5]],"date-time":"2014-06-05T00:00:00Z","timestamp":1401926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Beh\u00e7et's disease (<jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>) is a systemic vasculitis of unknown cause with a higher prevalence along the ancient Silk Road. Beh\u00e7et's occasional familial aggregation and its close association with genes of major histocompatibility complexes justify that genetic factors play an important role in the development of the disease. In this study, we evaluated the association of multidrug resistance (<jats:italic><jats:styled-content style=\"fixed-case\">MDR<\/jats:styled-content>1<\/jats:italic>) C3435T polymorphism with the severity of<jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We investigated the distribution of<jats:italic><jats:styled-content style=\"fixed-case\">MDR<\/jats:styled-content>1<\/jats:italic>C3435T polymorphism in 69 patients from the Iranian Azeri Turks group with<jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>and 92 ethnically sex\u2010matched healthy controls, via the polymerase chain reaction\u2013restriction fragment length polymorphism technique.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>Although there was no significant association of<jats:italic><jats:styled-content style=\"fixed-case\">MDR<\/jats:styled-content>1<\/jats:italic>C3435T polymorphism between two groups of patients and healthy controls, our data showed a substantial association of<jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>genotype with the development of several clinical features, including erythema nodosum (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.001,<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a02.686, 95%), pseudofolliculitis (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.002,<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a02.812, 95%), and skin lesions (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.040,<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a01.934, 95%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results suggest that<jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>genotype is a risk factor for the development of some clinical features of<jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>in patients from the Iranian Azeri Turk ethnic group.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.12540","type":"journal-article","created":{"date-parts":[[2014,6,5]],"date-time":"2014-06-05T08:37:52Z","timestamp":1401957472000},"page":"1235-1240","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<i><scp>MDR<\/scp>1<\/i>C3435T polymorphism associated with the development of clinical features in Beh\u00e7et's disease in Iranian Azeri Turkish patients"],"prefix":"10.1111","volume":"53","author":[{"given":"Mortaza","family":"Bonyadi","sequence":"first","affiliation":[{"name":"Center of Excellence for Biodiversity Faculty of Natural Sciences University of Tabriz Tabriz Iran"},{"name":"Liver and Gastrointestinal Disease Research Center Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monireh","family":"Gholizadeh","sequence":"additional","affiliation":[{"name":"Center of Excellence for Biodiversity Faculty of Natural Sciences University of Tabriz Tabriz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahboob","family":"Soltan\u2010Ali","sequence":"additional","affiliation":[{"name":"Department of Community and Family Medicine School of Medicine National Public Health Management Centre Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,6,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2006.11.010"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2006.09.009"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-0172(00)80015-3"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2008.08.009"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199910213411707"},{"key":"e_1_2_6_7_1","first-page":"1078","article-title":"Criteria for diagnosis of Beh\u00e7et's disease. 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