{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:20:29Z","timestamp":1791188429190,"version":"4.1.0"},"reference-count":70,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,6,25]],"date-time":"2014-06-25T00:00:00Z","timestamp":1403654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Hidradenitis suppurativa (\n                    <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>\n                    ) is a chronic relapsing inflammatory disease of follicular occlusion characterized by boils, sinus tracts, fistulae, and scarring. It has a significant underestimated morbidity. Antimicrobial, immunosuppressive, anti\u2010androgenic, and surgical approaches have been used with varying results. Knowledge of the pathogenesis of\n                    <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>\n                    is fragmented, and treatment choices have hitherto been empiric without an exact understanding of the scientific basis for their use. Tumor necrosis factor\u2010\u03b1 inhibitors have shown promise in the treatment of\n                    <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>\n                    in recent years, and the concept of\n                    <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>\n                    as an immunological condition has come to the fore. The focus of this review is to discuss the immunological abnormalities underpinning\n                    <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>\n                    as elucidated to date.\n                  <\/jats:p>","DOI":"10.1111\/ijd.12550","type":"journal-article","created":{"date-parts":[[2014,6,25]],"date-time":"2014-06-25T02:54:00Z","timestamp":1403664840000},"page":"1186-1196","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":98,"title":["Hidradenitis suppurativa: the role of immune dysregulation"],"prefix":"10.1111","volume":"53","author":[{"given":"Genevieve","family":"Kelly","sequence":"first","affiliation":[{"name":"Dermatology Research Group Education and Research Centre St. Vincent's University Hospital Tallaght Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl M.","family":"Sweeney","sequence":"additional","affiliation":[{"name":"Dermatology Research Group Education and Research Centre St. Vincent's University Hospital Tallaght Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne\u2010Marie","family":"Tobin","sequence":"additional","affiliation":[{"name":"Department of Dermatology Adelaide and Meath Hospital Incorporating the National Children's Hospital Tallaght Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Kirby","sequence":"additional","affiliation":[{"name":"Dermatology Research Group Education and Research Centre St. Vincent's University Hospital Tallaght Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,6,25]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.11.911"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.06.020"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(96)90321-7"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2012.07.027"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/13547500903075218"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.08.061"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1082"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0866"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.09.021"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2001.04137.x"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2012.04468.x"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2011.08.047"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1990.tb06264.x"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1995.tb02624.x"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2009.00915.x"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.10034.x"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1985.tb02037.x"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03476.x"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700272"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1196284"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2004.09.014"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10459.x"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.42"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.162"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1977.01640040058008"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1988.01670070031014"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/00015550152384209"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09430.x"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2010.328"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/00054725-200111000-00008"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.06.050"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10339.x"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2010.72"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04123.x"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri702"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-011-1169-1"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10254.x"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0903907"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10765.x"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1492"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0749"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07556.x"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10698.x"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2011.315"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20060285"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.01.040"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2012.01552.x"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2711"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.19.1.683"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-9-217"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2012.03.044"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20061308"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.07.010"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1001"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1261"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01355"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2011.168"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12027"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.23.021704.115806"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.4666"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.07.020"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.12.033"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1159\/000086650"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200940041"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1996.d01-1069.x"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10643.x"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08425.x"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.02.015"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12068"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1103102"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fijd.12550","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.12550","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T04:29:20Z","timestamp":1696307360000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.12550"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,25]]},"references-count":70,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["10.1111\/ijd.12550"],"URL":"https:\/\/doi.org\/10.1111\/ijd.12550","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,25]]},"assertion":[{"value":"2014-06-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}