{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:54:25Z","timestamp":1787964865954,"version":"build-2784847793"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,7,11]],"date-time":"2014-07-11T00:00:00Z","timestamp":1405036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2015,4]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Rosacea is a common, chronic, and inflammatory skin disease. The burden imposed by this condition requires that new topical treatments be sought to enlarge the arsenal of drugs available in order to better manage this disease.<\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n \n This study was conducted to carry out an\n in vitro<\/jats:italic>\n \/\n in vivo<\/jats:italic>\n evaluation of the antimicrobial activity of 3% praziquantel (\n PZQ<\/jats:styled-content>\n ) ointment and to determine its efficacy and safety in the treatment of rosacea.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Patients with rosacea (\n n\u00a0<\/jats:italic>\n =\u00a065) participated in a 16\u2010week, randomized, single\u2010blind pilot study of the effects of twice\u2010daily monotherapy with 3%\n PZQ<\/jats:styled-content>\n ointment vs. placebo (vehicle ointment). Efficacy was assessed clinically using the Investigator's Global Assessment Scale (\n IGAS<\/jats:styled-content>\n ) and the Clinical Erythema Assessment Scale (\n CEAS<\/jats:styled-content>\n ). Patients\u2019 quality of life was also determined using the Dermatology Life Quality Index (\n DLQI<\/jats:styled-content>\n ). The antimicrobial potential of 3%\n PZQ<\/jats:styled-content>\n ointment was assessed by agar diffusion assay.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Scores on the\n IGAS<\/jats:styled-content>\n and\n CEAS<\/jats:styled-content>\n showed\n PZQ<\/jats:styled-content>\n ointment to have a statistically significant therapeutic advantage over the placebo treatment (\n P\u00a0<\/jats:italic>\n <\u00a00.001). At week 16, the\n PZQ<\/jats:styled-content>\n group demonstrated a statistically significant greater reduction in\n CEAS<\/jats:styled-content>\n score than the placebo group (\n P<\/jats:italic>\n \u00a0<\u00a00.001). Analysis of\n CEAS<\/jats:styled-content>\n scores showed that 41.9% of patients in the\n PZQ<\/jats:styled-content>\n group and 18.2% of those in the placebo group achieved a\n CEAS<\/jats:styled-content>\n score equivalent to a rating of \u201cnone\u201d. Mean scores on the\n DLQI<\/jats:styled-content>\n at baseline and at the end of the study were, respectively, 15.8 and 4.1 in the praziquantel group. The\n PZQ<\/jats:styled-content>\n \u2010treated group also experienced a statistically significant improvement in comparison with the placebo group at week\u00a016 (\n P\u00a0<\/jats:italic>\n <\u00a00.001). The inhibitory zone indicating the extent of antimicrobial activity of 3%\n PZQ<\/jats:styled-content>\n ointment ranged from 6\u00a0mm to 17\u00a0mm. No serious treatment\u2010related adverse events occurred in either treatment group.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Use of 3%\n PZQ<\/jats:styled-content>\n ointment twice daily for 12\u00a0weeks resulted in significantly better effects than a placebo treatment in improving rosacea and the patient's quality of life.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ijd.12552","type":"journal-article","created":{"date-parts":[[2014,7,11]],"date-time":"2014-07-11T04:17:51Z","timestamp":1405052271000},"page":"481-487","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Clinical and experimental assessment of the effects of a new topical treatment with praziquantel in the management of rosacea"],"prefix":"10.1111","volume":"54","author":[{"given":"Mohamed Ridha","family":"Bribeche","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology Zaporozhye State Medical University Zaporozhye Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valery P.","family":"Fedotov","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Zaporozhye State Medical University Zaporozhye Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitaly V.","family":"Gladichev","sequence":"additional","affiliation":[{"name":"Department of Drug Chemistry and Technologies Zaporozhye State Medical University Zaporozhye Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daria M.","family":"Pukhalskaya","sequence":"additional","affiliation":[{"name":"Department of Drug Chemistry and Technologies Zaporozhye State Medical University Zaporozhye Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia L.","family":"Kolitcheva","sequence":"additional","affiliation":[{"name":"Department of Microbiology Zaporozhye State Medical University Zaporozhye Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,7,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.120625"},{"key":"e_1_2_6_3_1","first-page":"419","article-title":"An epidemiological study of rosacea","volume":"69","author":"Berg M","year":"1989","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_6_4_1","first-page":"1","article-title":"Prevalence of skin diseases in a population \u2013 a census study from the Faroe Islands","volume":"11","author":"Lomholt G","year":"1964","journal-title":"Dan Med Bull"},{"key":"e_1_2_6_5_1","first-page":"385","article-title":"Quality of life in patients with rosacea","volume":"65","author":"Salamon M","year":"2008","journal-title":"Przegl 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