{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T17:56:58Z","timestamp":1761674218921},"reference-count":43,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,12,12]],"date-time":"2014-12-12T00:00:00Z","timestamp":1418342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Beh\u00e7et's disease (<jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>) is a chronic, multisystem, inflammatory pan\u2010vasculitis of unknown etiology, with heterogeneous presentations in different parts of the world. It commonly involves the mucosae, skin, joints, eyes, and central nervous system. Beh\u00e7et's disease is considered to represent an autoimmune reaction triggered by a yet to be identified infectious agent in a genetically predisposed person. It most commonly affects persons of Mediterranean or Far Eastern origin and is considered rare among Black Africans.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study was conducted to document clinical presentations of <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> in Nigerians.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective study of the clinical and laboratory parameters of patients who attended dermatology and rheumatology clinics between 2007 and 2011 was carried out.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifteen patients (nine males, six females) were diagnosed with <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> at a mean age of 33\u00a0years. The mean age of onset of disease was 27\u00a0years. Oral ulceration was present in 100% of subjects and was the most frequent onset lesion, followed by genital ulceration in 93%. Skin, joint, vascular, gastrointestinal, and central nervous system (<jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content>) lesions occurred in 87, 80, 33, 20, and 13% of patients, respectively. Pathergy tests were positive in 38% of patients. Psychomorbidity was present in 60%. Remission was achieved with corticosteroids, nonsteroidal anti\u2010inflammatory drugs, and disease\u2010modifying anti\u2010rheumatic drugs. Mortality was zero, but 27% of patients were disabled by blindness and 7% by <jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content> involvement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This is the first report on <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> in a sample of Nigerians. The clinical phenotype of <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> follows the Middle Eastern pattern. The small number of patients may reflect the rarity of <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> in Nigerians or the poor ascertainment of <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> by relevant clinicians.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.12554","type":"journal-article","created":{"date-parts":[[2014,12,12]],"date-time":"2014-12-12T11:13:38Z","timestamp":1418382818000},"page":"889-897","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Clinical presentations of Beh\u00e7et's disease among Nigerians: a 4\u2010year prospective study"],"prefix":"10.1111","volume":"54","author":[{"given":"Frances O. 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