{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:36:58Z","timestamp":1789173418589,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,11,26]],"date-time":"2014-11-26T00:00:00Z","timestamp":1416960000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Psoriasis is an inflammatory skin disease that can considerably affect a patient's quality of life. Environmental and genetic factors, as well as superantigens and toxins from<jats:italic>Candida<\/jats:italic>species, may play various roles in the exacerbation and persistence of psoriasis. In the present study, we evaluated candidal colonization and specific humoral responses against<jats:italic>Candida albicans<\/jats:italic>in patients with psoriasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 100 patients with psoriasis vulgaris and 50 healthy control individuals were enrolled in the study. Skin and oral specimens from all participants were cultured on CHROMagar<jats:italic>Candida<\/jats:italic>medium. Isolated yeast\u2010like fungi were identified using the sequence of the D1\/D2 domain of the 26S<jats:styled-content style=\"fixed-case\">rRNA<\/jats:styled-content>gene. Enzyme\u2010linked immunosorbent assays (ELISAs) were used to detect immunoglobulin M (IgM), IgA, and IgG antibodies against<jats:italic>C.\u00a0albicans<\/jats:italic>in sera of patients and healthy individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>Candida<\/jats:italic>species were isolated from the skin of 15% of patients and 4% of controls and from oral specimens of 60% of patients and 20% of controls. There was a significant difference in candidal colonization between patients and controls (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). Serum IgM, IgA, and IgG levels against<jats:italic>C.\u00a0albicans<\/jats:italic>were significantly lower in patients with psoriasis than in controls (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). There was no significant association between serum levels of specific antibodies against<jats:italic>C.\u00a0albicans<\/jats:italic>or the frequency of candidal colonization with the clinical severity of the disease (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results of the present study show a higher rate of candidal colonization in patients with psoriasis in comparison with controls and a reduction in humoral immune responses in patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.12562","type":"journal-article","created":{"date-parts":[[2014,11,26]],"date-time":"2014-11-26T14:36:58Z","timestamp":1417012618000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Evaluation of candidal colonization and specific humoral responses against<i>Candida albicans<\/i>in patients with psoriasis"],"prefix":"10.1111","volume":"53","author":[{"given":"Mehdi","family":"Taheri Sarvtin","sequence":"first","affiliation":[{"name":"Department of Medical Mycology and Parasitology School of Medicine, Jiroft University of Medical Sciences Jiroft Iran"},{"name":"Department of Medical Mycology and Parasitology School of Medicine Kerman University of Medical Sciences Kerman Iran"},{"name":"Invasive Fungi Research Center Mazandaran University of Medical Sciences Sari Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tahereh","family":"Shokohi","sequence":"additional","affiliation":[{"name":"Invasive Fungi Research Center Mazandaran University of Medical Sciences Sari Iran"},{"name":"Department of Medical Mycology and Parasitology School of Medicine Mazandaran University of Medical Sciences Sari Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zohreh","family":"Hajheydari","sequence":"additional","affiliation":[{"name":"Department of Medical 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