{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:08:51Z","timestamp":1791212931404,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,3,13]],"date-time":"2015-03-13T00:00:00Z","timestamp":1426204800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2015,8]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Patients with chronic lymphocytic leukemia (CLL<\/jats:styled-content>), small lymphocytic lymphoma (SLL<\/jats:styled-content>), or non\u2010Hodgkin lymphoma (NHL<\/jats:styled-content>) are at increased risk for the development of skin malignancies.<\/jats:p><\/jats:sec>Objectives<\/jats:title>This study was conducted to estimate the incidences of rare skin malignancies in patients with CLL<\/jats:styled-content>\/SLL<\/jats:styled-content> or NHL<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>Patients with a diagnosis of CLL<\/jats:styled-content>\/SLL<\/jats:styled-content> or NHL<\/jats:styled-content> recorded in the Surveillance, Epidemiology and End Results (SEER<\/jats:styled-content>) database during 1992\u20132007 were identified. Diagnoses of specific skin malignancies were identified from SEER<\/jats:styled-content> files.<\/jats:p><\/jats:sec>Results<\/jats:title>During 1992\u20132007, a total of 128,674 patients with first diagnoses of CLL<\/jats:styled-content>\/SLL<\/jats:styled-content> or NHL<\/jats:styled-content> were recorded in SEER<\/jats:styled-content>; 4743 were excluded because follow\u2010up data were unavailable. Among the remaining 123,931 patients, 28,964 had CLL<\/jats:styled-content>\/SLL<\/jats:styled-content> and 94,967 had NHL<\/jats:styled-content>. Standardized incidence ratios (SIR<\/jats:styled-content>s) for invasive malignant melanoma, Merkel cell carcinoma, malignant fibrous histiocytoma, dermatofibrosarcoma protuberans, Kaposi's sarcoma, and sebaceous carcinoma were 2.3, 8.2, 3.6, 2.5, 2.9, and 1.4, respectively, in CLL<\/jats:styled-content>\/SLL<\/jats:styled-content> patients and 1.6, 3.2, 1.5, 1.3, 17.6, and 0.8, respectively, in NHL<\/jats:styled-content> patients. When invasive melanoma was stratified by patient age and sex, the highest SIR (17.8) was found in men aged 0\u201349 years with CLL (P\u00a0<\/jats:italic><\u00a00.001).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Patients with CLL<\/jats:styled-content>\/SLL<\/jats:styled-content> or NHL<\/jats:styled-content> have a higher risk for the subsequent development of rare skin cancers. Given the more aggressive nature of these malignancies in this setting, regular monitoring for the development and prompt treatment of cutaneous malignancy is prudent in patients with NHL<\/jats:styled-content> and particularly in patients with CLL<\/jats:styled-content>. Regular use of sun protection may decrease the morbidity associated with skin cancer in this immunosuppressed population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.12564","type":"journal-article","created":{"date-parts":[[2015,3,14]],"date-time":"2015-03-14T00:55:13Z","timestamp":1426294513000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Increased incidence of malignant melanoma and other rare cutaneous cancers in the setting of chronic lymphocytic leukemia"],"prefix":"10.1111","volume":"54","author":[{"given":"Jerry D.","family":"Brewer","sequence":"first","affiliation":[{"name":"Division of Dermatologic Surgery Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tait D.","family":"Shanafelt","sequence":"additional","affiliation":[{"name":"Division of Hematology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy G.","family":"Call","sequence":"additional","affiliation":[{"name":"Division of Hematology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R.","family":"Cerhan","sequence":"additional","affiliation":[{"name":"Division of Epidemiology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randall K.","family":"Roenigk","sequence":"additional","affiliation":[{"name":"Division of Dermatologic Surgery Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy L.","family":"Weaver","sequence":"additional","affiliation":[{"name":"Division of Biomedical Statistics and Informatics Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clark C.","family":"Otley","sequence":"additional","affiliation":[{"name":"Division of Dermatologic Surgery Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-77574-6_8"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20073"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(73)93174-7"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.310.6993.1491"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600692"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22765"},{"key":"e_1_2_6_8_1","first-page":"105","article-title":"Merkel cell carcinoma and immunosuppression: report of three cases and review of therapeutic options","volume":"40","author":"Groger A","year":"2008","journal-title":"Handchir Mikrochir Plast Chir"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcpc0803063"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.05982.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20616"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605306"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199912150-00015"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2011.01947.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.4065\/mcp.2010.0720"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.17.5398"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910610606"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-8411(92)90055-U"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24931"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605733"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2008.02386.x"},{"key":"e_1_2_6_22_1","first-page":"35","article-title":"Risk for second non\u2010lymphoid neoplasms in chronic lymphocytic leukemia","volume":"9","author":"Dasanu CA","year":"2007","journal-title":"MedGenMed"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/84.18.1422"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-004-0013-7"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-03-0187"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1996.169"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/CEJ.0b013e3282b6fd0f"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2012.04.018"},{"key":"e_1_2_6_29_1","first-page":"571","article-title":"Skin cancer in patients with chronic lymphocytic leukemia and non\u2010Hodgkin lymphoma","volume":"10","author":"Onajin O","year":"2012","journal-title":"Clin Adv Hematol Oncol"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24386"},{"key":"e_1_2_6_31_1","first-page":"B4485","article-title":"On the etiology of Hodgkin lymphoma","volume":"59","author":"Hjalgrim H","year":"2012","journal-title":"Dan Med J"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1080\/00039899809605725"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1080\/02841860701753697"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-199507000-00012"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.27522"},{"key":"e_1_2_6_36_1","unstructured":"TherneauT.Expected Survival based on Hazard Rates (Updated). Technical Report Series No. 63.Rochester MN:Mayo Clinic Department of Health Sciences Research 1999."},{"key":"e_1_2_6_37_1","volume-title":"PERSONYRS: a SAS procedure for person year analyses","author":"Bergstralh E","year":"1986"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03610.x"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.34.9605"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2007.06856.x"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20010901)92:5<1325::AID-CNCR1454>3.0.CO;2-E"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2009.01447.x"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.08.055"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.140.8.985"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2005.31006"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fijd.12564","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.12564","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T10:26:36Z","timestamp":1696242396000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.12564"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,13]]},"references-count":44,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["10.1111\/ijd.12564"],"URL":"https:\/\/doi.org\/10.1111\/ijd.12564","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,13]]},"assertion":[{"value":"2013-04-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-11-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-03-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}