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Only studies investigating the association between HLA<\/jats:styled-content>\u2010B*1502<\/jats:italic> and lamotrigine\u2010induced SJS<\/jats:styled-content>\/TEN<\/jats:styled-content> were included. We then performed a meta\u2010analysis of the data in these studies.<\/jats:p><\/jats:sec>Results<\/jats:title>Four studies including a total of 12 patients with SJS<\/jats:styled-content>\/TEN<\/jats:styled-content> and 128 lamotrigine\u2010tolerant control subjects were identified. The HLA<\/jats:styled-content>\u2010B*1502<\/jats:italic> allele was present in 33.3% (four of 12) of lamotrigine\u2010induced SJS<\/jats:styled-content>\/TEN<\/jats:styled-content> cases but in only 9.4% (12 of 128) of lamotrigine\u2010tolerant controls. The occurrence of SJS<\/jats:styled-content>\/TEN<\/jats:styled-content> was thus associated with the presence of the HLA<\/jats:styled-content>\u2010B*1502<\/jats:italic> allele (odds ratio: 4.98, 95% confidence interval 1.43\u201317.28; P\u00a0<\/jats:italic><\u00a00.05).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>We found a statistical association between HLA<\/jats:styled-content>\u2010B*1502<\/jats:italic> and lamotrigine\u2010induced SJS<\/jats:styled-content>\/TEN<\/jats:styled-content> in Han Chinese subjects. Future studies with larger sample sizes are suggested to verify the results.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.12570","type":"journal-article","created":{"date-parts":[[2014,11,27]],"date-time":"2014-11-27T06:59:57Z","timestamp":1417071597000},"page":"488-493","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Association of HLA<\/scp>\u2010B*1502<\/i> allele with lamotrigine\u2010induced Stevens\u2013Johnson syndrome and toxic epidermal necrolysis in Han Chinese subjects: a meta\u2010analysis"],"prefix":"10.1111","volume":"54","author":[{"given":"Tao","family":"Zeng","sequence":"first","affiliation":[{"name":"Institute of Neuroscience and the Second Affiliated Hospital of Guangzhou Medical University Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China Guangzhou China"},{"name":"Department of Neurology Guangzhou First People's Hospital Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue\u2010Sheng","family":"Long","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience and the Second Affiliated Hospital of Guangzhou Medical University Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu\u2010Li","family":"Min","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience and the Second Affiliated Hospital of Guangzhou Medical University Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei\u2010Ping","family":"Liao","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience and the Second Affiliated Hospital of Guangzhou Medical University Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Wu","family":"Shi","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience and the Second Affiliated Hospital of Guangzhou Medical University Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,11,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1990.01670250049006"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1001\/archderm.1990.01670320127028","article-title":"Incidence of toxic epidermal necrolysis in Italy","volume":"126","author":"Naldi L","year":"1990","journal-title":"Arch Dermatol"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1990.01670250043005"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1991.01680050083008"},{"key":"e_1_2_7_6_1","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1001\/archderm.1991.01680050075007","article-title":"A population\u2010based study of Stevens\u2013Johnson syndrome. 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