{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:16:27Z","timestamp":1740125787925,"version":"3.37.3"},"reference-count":11,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,9,30]],"date-time":"2014-09-30T00:00:00Z","timestamp":1412035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004423","name":"World Health Organization","doi-asserted-by":"publisher","award":["L42\/181\/192"],"award-info":[{"award-number":["L42\/181\/192"]}],"id":[{"id":"10.13039\/100004423","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study was conducted to evaluate the effectiveness of uniform multi\u2010drug therapy (<jats:styled-content style=\"fixed-case\">UMDT<\/jats:styled-content>) in patients with multibacillary (<jats:styled-content style=\"fixed-case\">MB<\/jats:styled-content>) leprosy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Newly detected <jats:styled-content style=\"fixed-case\">MB<\/jats:styled-content> leprosy patients were treated with six\u00a0months of <jats:styled-content style=\"fixed-case\">UMDT<\/jats:styled-content> as recommended by the World Health Organization (<jats:styled-content style=\"fixed-case\">WHO<\/jats:styled-content>). The effectiveness of treatment was evaluated by clinical status and skin smear tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At the start, 114 patients were recruited, examined, and treated. These patients were re\u2010examined and followed annually for up to six\u00a0years. A total of 75 (65.8%) patients completed six\u00a0years of follow\u2010up. Dropouts were attributable to death, severe drug reactions, and other reasons. The mean\u00a0\u00b1\u00a0standard deviation bacteriological index (<jats:styled-content style=\"fixed-case\">BI<\/jats:styled-content>) of all patients decreased from 3.01\u00a0\u00b1\u00a01.50 before treatment to 0.02\u00a0\u00b1\u00a01.84 at the end of year 6, reflecting a mean annual decrease of 0.50. The rate of smear negativity in all patients was 98.7% at the end of year 6 of follow\u2010up. A total of 53 leprosy reactions were observed. One patient relapsed 13\u00a0months after the cessation of treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A 6\u2010month administration of <jats:styled-content style=\"fixed-case\">UMDT<\/jats:styled-content> is effective in <jats:styled-content style=\"fixed-case\">MB<\/jats:styled-content> leprosy patients. The changes in <jats:styled-content style=\"fixed-case\">BI<\/jats:styled-content> values and the frequency of leprosy reactions were similar to those cited in reports in the literature of patients treated with 1\u2010 or 2\u2010year regimens of <jats:styled-content style=\"fixed-case\">MDT<\/jats:styled-content>. However, further research should be conducted to confirm the present results.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ijd.12573","type":"journal-article","created":{"date-parts":[[2014,9,30]],"date-time":"2014-09-30T09:24:28Z","timestamp":1412069068000},"page":"315-318","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Six years' follow\u2010up of multibacillary leprosy patients treated with uniform multi\u2010drug therapy in China"],"prefix":"10.1111","volume":"54","author":[{"given":"Jianping","family":"Shen","sequence":"first","affiliation":[{"name":"Department of Leprosy Control Institute of Dermatology Chinese Academy of Medical Sciences Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liangbin","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Leprosy Control Institute of Dermatology Chinese Academy of Medical Sciences Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meiwen","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Leprosy Control Institute of Dermatology Chinese Academy of Medical Sciences Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinlan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Leprosy Control Guizhou Provincial Center for Disease Control and Prevention Guiyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiufeng","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Leprosy Control Wenshan District Institute of Dermatology Wenshan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guocheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Leprosy Control Institute of Dermatology Chinese Academy of Medical Sciences Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,9,30]]},"reference":[{"volume-title":"Chemotherapy of Leprosy for Control Programs","year":"1982","author":"World Health Organization Study Group","key":"e_1_2_6_2_1"},{"key":"e_1_2_6_3_1","unstructured":"World Health Organization Expert Committee on Leprosy 1998 WHO Geneva"},{"volume-title":"Report on Third Meeting of the WHO Technical Advisory Group on Elimination of Leprosy","year":"2002","author":"World Health Organization","key":"e_1_2_6_4_1"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0102-311X2007000400009"},{"key":"e_1_2_6_6_1","first-page":"553","article-title":"Efficacy of uniform multi\u2010drug therapy for treatment of multibacillary leprosy patients based on bacterial index and leprosy reaction","volume":"45","author":"Yu M","year":"2012","journal-title":"China J Dermatol"},{"key":"e_1_2_6_7_1","first-page":"6","article-title":"Bacterial change and relapse after multi\u2010drug therapy in 157 cases of multibacillary leprosy","volume":"14","author":"Li W","year":"1998","journal-title":"China Lepr J"},{"key":"e_1_2_6_8_1","first-page":"61","article-title":"Observation of effect of multi\u2010drug therapy in multibacillary leprosy for 5\u00a0years","volume":"6","author":"Li W","year":"1990","journal-title":"China Lepr J"},{"key":"e_1_2_6_9_1","first-page":"255","article-title":"Results of multi\u2010drug therapy on multibacillary leprosy and follow\u2010up of 10\u00a0years","volume":"29","author":"Shen J","year":"1996","journal-title":"Chin J Dermatol"},{"key":"e_1_2_6_10_1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.47276\/lr.81.1.41","article-title":"The effect of corticosteroids usage on bacterial killing, clearance and nerve damage in leprosy, Part 3. Study of two comparable groups of 100 multibacillary (MB) patients each, treated with MDT+ steroids vs. MDT alone, assessed at 6\u00a0months post\u2010release from 12\u00a0months MDT","volume":"81","author":"Shetty VP","year":"2010","journal-title":"Lepr Rev"},{"key":"e_1_2_6_11_1","doi-asserted-by":"crossref","first-page":"308","DOI":"10.47276\/lr.83.3.308","article-title":"Primary results of clinical trial for uniform multi\u2010drug therapy for leprosy patients in Brazil (U\u2010MDT\/CT\u2010BR): reaction frequency in multibacillary patients","volume":"83","author":"Panna ML","year":"2012","journal-title":"Lepr Rev"},{"key":"e_1_2_6_12_1","doi-asserted-by":"crossref","first-page":"254","DOI":"10.47276\/lr.79.3.254","article-title":"Erythema nodosum leprosum in Nepal: a retrospective study of clinical features and response to treatment with prednisolone or thalidomide","volume":"79","author":"Feuth M","year":"2008","journal-title":"Lepr Rev"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fijd.12573","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.12573","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T04:20:45Z","timestamp":1696306845000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.12573"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,30]]},"references-count":11,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["10.1111\/ijd.12573"],"URL":"https:\/\/doi.org\/10.1111\/ijd.12573","archive":["Portico"],"relation":{},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"type":"print","value":"0011-9059"},{"type":"electronic","value":"1365-4632"}],"subject":[],"published":{"date-parts":[[2014,9,30]]},"assertion":[{"value":"2014-09-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}