{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T16:28:18Z","timestamp":1775147298730,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,9,10]],"date-time":"2014-09-10T00:00:00Z","timestamp":1410307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Suleyman Demirel University Research Project","award":["SDU 2515-M-10"],"award-info":[{"award-number":["SDU 2515-M-10"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Dermatology"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    H1\u2010receptor inhibiting drugs, namely loratadine and cetirizine, were frequently used in treatment of chronic urticaria. Urticarial weal and flare reactions, a neurogenic reflex due to neuropeptides, were reported to be more effectively inhibited by cetirizine than loratadine. The aim of this study was to determine and compare the effects of systemic loratadine and cetirizine treatments on serum levels of selected neuropeptides in chronic urticaria. Treatment groups of either systemic loratadine or cetirizine (10\u00a0mg\/d), consisting of 16 and 22 patients, respectively, were included. Serum levels of stem cell factor (\n                    <jats:styled-content style=\"fixed-case\">SCF<\/jats:styled-content>\n                    ), neuropeptide Y (\n                    <jats:styled-content style=\"fixed-case\">NPY<\/jats:styled-content>\n                    ), calcitonin gene\u2010related peptide (\n                    <jats:styled-content style=\"fixed-case\">CGRP<\/jats:styled-content>\n                    ), nerve growth factor (\n                    <jats:styled-content style=\"fixed-case\">NGF<\/jats:styled-content>\n                    ), vasoactive intestinal peptide (\n                    <jats:styled-content style=\"fixed-case\">VIP<\/jats:styled-content>\n                    ), and substance P (\n                    <jats:styled-content style=\"fixed-case\">SP<\/jats:styled-content>\n                    ) were detected before and after one\u00a0week of treatment with antihistamines. Serum\n                    <jats:styled-content style=\"fixed-case\">NPY<\/jats:styled-content>\n                    and\n                    <jats:styled-content style=\"fixed-case\">VIP<\/jats:styled-content>\n                    levels were significantly decreased when compared before and after treatment with antihistamines (\n                    <jats:italic>P\u00a0<\/jats:italic>\n                    &lt;\u00a00.001 and\n                    <jats:italic>P\u00a0<\/jats:italic>\n                    &lt;\u00a00.01, respectively).\n                    <jats:styled-content style=\"fixed-case\">SCF<\/jats:styled-content>\n                    and\n                    <jats:styled-content style=\"fixed-case\">NGF<\/jats:styled-content>\n                    values were also decreased after antihistamine treatment (\n                    <jats:italic>P\u00a0<\/jats:italic>\n                    &lt;\u00a00.05). Post\u2010treatment levels of\n                    <jats:styled-content style=\"fixed-case\">CGRP<\/jats:styled-content>\n                    were significantly higher compared with pretreatment values, while no significant difference was detected between pre and post treatment levels of\n                    <jats:styled-content style=\"fixed-case\">SP<\/jats:styled-content>\n                    . Cetirizine was significantly more effective than loratadine on lowering serum levels of\n                    <jats:styled-content style=\"fixed-case\">SCF<\/jats:styled-content>\n                    among the other neuropeptides. Systemic loratadine and cetirizine treatments in patients with chronic urticaria precisely caused variations in serum levels of neuropeptides. The predominant effect of cetirizine compared to loratadine on reducing serum\n                    <jats:styled-content style=\"fixed-case\">SCF<\/jats:styled-content>\n                    levels might be explained with anti\u2010inflammatory properties of cetirizine.\n                  <\/jats:p>","DOI":"10.1111\/ijd.12590","type":"journal-article","created":{"date-parts":[[2014,9,10]],"date-time":"2014-09-10T22:50:15Z","timestamp":1410389415000},"page":"1526-1530","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Effects of loratadine and cetirizine on serum levels of neuropeptides in patients with chronic urticaria"],"prefix":"10.1111","volume":"53","author":[{"given":"Pinar Y.","family":"Ba\u015fak","sequence":"first","affiliation":[{"name":"Departments of Dermatology Faculty of Medicine S\u00fcleyman Demirel University Isparta Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huseyin","family":"Vural","sequence":"additional","affiliation":[{"name":"Departments of Biochemistry Faculty of Medicine S\u00fcleyman Demirel University Isparta Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oya O.","family":"Kazanoglu","sequence":"additional","affiliation":[{"name":"Departments of Dermatology Faculty of Medicine S\u00fcleyman Demirel University Isparta Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ijlal","family":"Erturan","sequence":"additional","affiliation":[{"name":"Departments of Dermatology Faculty of Medicine S\u00fcleyman Demirel University Isparta Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Halil I.","family":"Buyukbayram","sequence":"additional","affiliation":[{"name":"Departments of Biochemistry Faculty of Medicine S\u00fcleyman Demirel University Isparta Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,9,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2005.10.002"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2000.80.3.979"},{"key":"e_1_2_6_4_1","first-page":"99","volume-title":"Dermatology","author":"Yosipovitch G","year":"2012"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1006\/brbi.1998.0541"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8635(05)70368-5"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1991.tb14173.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.1999.00726.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1998.02217.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2007.00522.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.12.1343"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.1997.d01-502.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0923-1811(92)90016-5"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000237310"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000090982"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)91000-X"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03350684"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2007.12.002"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.05167.x"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.20.10955"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2008.08.011"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s000110050567"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00637746"},{"key":"e_1_2_6_24_1","first-page":"139","article-title":"Compared peripheral H1 inhibiting effects of cetirizine 2 HCl and loratadine","volume":"65","author":"Rihoux JP","year":"1990","journal-title":"Ann Allergy"},{"key":"e_1_2_6_25_1","first-page":"190","article-title":"Use of cetirizine to investigate non\u2010H1 effects of second\u2010generation antihistamines","volume":"68","author":"Townley RG","year":"1992","journal-title":"Ann Allergy"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V100.13.4291"}],"container-title":["International Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fijd.12590","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ijd.12590","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T04:01:02Z","timestamp":1696392062000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijd.12590"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,10]]},"references-count":25,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["10.1111\/ijd.12590"],"URL":"https:\/\/doi.org\/10.1111\/ijd.12590","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718871787.793500278","asserted-by":"object"}]},"ISSN":["0011-9059","1365-4632"],"issn-type":[{"value":"0011-9059","type":"print"},{"value":"1365-4632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,10]]},"assertion":[{"value":"2014-09-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}